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Literature summary for 3.6.1.54 extracted from

  • Richie, D.; Takeoka, K.; Bojkovic, J.; Metzger, L.; Rath, C.; Sawyer, W.; Wei, J.; Dean, C.
    Toxic accumulation of lps pathway intermediates underlies the requirement of LpxH for growth of acinetobacter Baumannii ATCC 19606 (2016), PLoS ONE, 11, e0160918 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.54

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + H2O Acinetobacter baumannii
-
 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UMP
-
 ?
UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + H2O Acinetobacter baumannii ATCC 19606
-
 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UMP
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii
-
-
-
Acinetobacter baumannii D0C652
-
-
Acinetobacter baumannii ATCC 19606
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-
-
Acinetobacter baumannii ATCC 19606 D0C652
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + H2O
-
 Acinetobacter baumannii 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UMP
-
 ?
UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + H2O
-
 Acinetobacter baumannii ATCC 19606 2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl 1-phosphate + UMP
-
 ?

Synonyms

Synonyms Comment Organism
LpxH
-
 Acinetobacter baumannii
UDP-2,3-diacylglucosamine hydrolase
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 Acinetobacter baumannii

General Information

General Information Comment Organism
malfunction blockage of LpxH causes accumulation of detergent-like pathway intermediates that prevents cell growth Acinetobacter baumannii
malfunction enzyme depletion causes clear morphological defects in Acinetobacter baumannii strain ATCC 19606 Acinetobacter baumannii
metabolism the enzyme is involved in lipid A biosynthesis. The enzyme is essential for growth in the strain Acinetobacter baumannii ATCC 19606 Acinetobacter baumannii
physiological function the enzyme is essential for growth in Acinetobacter baumannii strain ATCC 19606 Acinetobacter baumannii