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Literature summary for 3.6.1.53 extracted from

  • Canales, J.; Pinto, R.M.; Costas, M.J.; Hernandez, M.T.; Miro, A.; Bernet, D.; Fernandez, A.; Cameselle, J.C.
    Rat liver nucleoside diphosphosugar or diphosphoalcohol pyrophosphatase different from nucleotide pyrophosphatase or phosphodiesterase I: substrate specificities of Mg2+- and/or Mn2+-depeneent hydrolases acting on ADP-ribose (1995), Biochim. Biophys. Acta, 1246, 167-177.
    View publication on PubMed

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.015
-
ADP-ribose pH 7.5, 37°C Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ required Rattus norvegicus
additional information Mg2+ cannot substitute for Mn2+ Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
gel filtration Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
18.2
-
pH 7.5, 37°C Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine 5'-diphospho-5'-adenosine + H2O
-
Rattus norvegicus AMP 45% of the activity with ADP-ribose ?
ADP + H2O 27% of the activity with ADP-ribose Rattus norvegicus AMP + phosphate
-
?
ADP-ribose + H2O
-
Rattus norvegicus AMP + D-ribose 5-phosphate
-
?
CDP-choline + H2O 140% of the activity with ADP-ribose Rattus norvegicus CMP + phosphocholine
-
?
CDP-ethanolamine + H2O 89% of the activity with ADP-ribose Rattus norvegicus CMP + phosphoethanolamine
-
?
CDP-glycerol + H2O 89% of the activity with ADP-ribose Rattus norvegicus CMP + phosphoglycerol
-
?
FAD + H2O
-
Rattus norvegicus ? 39% of the activity with ADP-ribose ?
IDP-ribose + H2O
-
Rattus norvegicus IMP + D-ribose 5-phosphate 105% of the activity with ADP-ribose ?
NAD+ + H2O
-
Rattus norvegicus ? 23% of the activity with ADP-ribose ?
NADH + H+ + H2O
-
Rattus norvegicus ? 25% of the activity with ADP-ribose ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
-
Rattus norvegicus

pI Value

Organism Comment pI Value Maximum pI Value
Rattus norvegicus isoelectric focusing
-
4.3