Literature summary for 3.6.1.5 extracted from

Channar, P.A.; Afzal, S.; Ejaz, S.A.; Saeed, A.; Larik, F.A.; Mahesar, P.A.; Lecka, J.; Sevigny, J.; Erben, M.F.; Iqbal, J.
Exploration of carboxy pyrazole derivatives synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile (2018), Eur. J. Med. Chem., 156, 461-478 .

Cloned(Commentary)

Cloned (Comment)	Organism
gene Entpd1, recombinant expression in COS-7 cells	Rattus norvegicus
gene Entpd2, recombinant expression in COS-7 cells	Rattus norvegicus
gene Entpd3, recombinant expression in COS-7 cells	Rattus norvegicus
gene Entpd8, recombinant expression in COS-7 cells	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism
(3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone	-	Rattus norvegicus
(3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone	-	Rattus norvegicus
(3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone	-	Rattus norvegicus
(3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone	-	Rattus norvegicus
(4-aminophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone	-	Rattus norvegicus
(4-aminophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone	-	Rattus norvegicus
(4-aminophenyl) (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)methanone	-	Rattus norvegicus
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (4-chlorophenyl)methanone	-	Rattus norvegicus
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (m-tolyl)methanone	-	Rattus norvegicus
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (naphthalen-2-yl)methanone	-	Rattus norvegicus
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (o-tolyl)methanone	-	Rattus norvegicus
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (p-tolyl)methanone	-	Rattus norvegicus
(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (pyridin-4-yl)methanone	-	Rattus norvegicus
(4-chlorophenyl) (3,5-dimethyl-1H-pyrazol-1-yl)methanone	-	Rattus norvegicus
(4-chlorophenyl) (3,5-dimethyl-4-(p-tolyloxy)-1H-pyrazol-1-yl)methanone	-	Rattus norvegicus
(E)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-3-phenylprop-2-en-1-one	-	Rattus norvegicus
(R)-1-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-2-(4-isobutylphenyl)propan-1-one	-	Rattus norvegicus
1-(4-aminobenzoyl)-5-methyl-1H-pyrazol-3(2H)-one	-	Rattus norvegicus
1-amino-4-[(naphthalen-1-yl)amino]-9,10-dioxo-9,10-dihydroanthracene-2-sulfonic acid	-	Rattus norvegicus
3,5-dimethyl-4-(naphthalen-2-yloxy)-1H-pyrazole	-	Rattus norvegicus
3-methyl-2-(4-methylbenzoyl)-1,2-dihydropyrazol-5-one	-	Rattus norvegicus
additional information	synthesis of aryl pyrazole derivatives using 1,3-dicarbonyl motifs. Synthesis of (3,5-dimethyl-1H-pyrazol-1-yl) (phenyl)methanones and (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (phenyl)methanones by grinding equimolar concentrations of pentane-2,4-dione and 3-chloropentane-2,4-dione with different arylhydrazides, respectively. The compounds can be regarded as 1H-pyrazol-1-yl-one analogues and represent drug like molecules. Structure-activity relationships, FT-IR, 1H NMR, 13C NMR and mass spectroscopic structure analysis, overview. Effects of these synthesized compounds on different isozymes of nucleoside triphosphate diphosphohydrolases, NTPDases; synthesis of aryl pyrazole derivatives using 1,3-dicarbonyl motifs. Synthesis of (3,5-dimethyl-1H-pyrazol-1-yl) (phenyl)methanones and (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (phenyl)methanones by grinding equimolar concentrations of pentane-2,4-dione and 3-chloropentane-2,4-dione with different arylhydrazides, respectively. The compounds can be regarded as 1H-pyrazol-1-yl-one analogues and represent drug like molecules. Structure-activity relationships, FT-IR, 1H NMR, 13C NMR and mass spectroscopic structure analysis, overview. Effects of these synthesized compounds on different isozymes of nucleoside triphosphate diphosphohydrolases, NTPDases; synthesis of aryl pyrazole derivatives using 1,3-dicarbonyl motifs. Synthesis of (3,5-dimethyl-1H-pyrazol-1-yl) (phenyl)methanones and (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (phenyl)methanones by grinding equimolar concentrations of pentane-2,4-dione and 3-chloropentane-2,4-dione with different arylhydrazides, respectively. The compounds can be regarded as 1H-pyrazol-1-yl-one analogues and represent drug like molecules. Structure-activity relationships, FT-IR, 1H NMR, 13C NMR and mass spectroscopic structure analysis, overview. Effects of these synthesized compounds on different isozymes of nucleoside triphosphate diphosphohydrolases, NTPDases; synthesis of aryl pyrazole derivatives using 1,3-dicarbonyl motifs. Synthesis of (3,5-dimethyl-1H-pyrazol-1-yl) (phenyl)methanones and (4-chloro-3,5-dimethyl-1H-pyrazol-1-yl) (phenyl)methanones by grinding equimolar concentrations of pentane-2,4-dione and 3-chloropentane-2,4-dione with different arylhydrazides, respectively. The compounds can be regarded as 1H-pyrazol-1-yl-one analogues and represent drug like molecules. Structure-activity relationships, FT-IR, 1H NMR, 13C NMR and mass spectroscopic structure analysis, overview. Effects of these synthesized compounds on different isozymes of nucleoside triphosphate diphosphohydrolases, NTPDases	Rattus norvegicus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	required	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + 2 H2O	Rattus norvegicus	-	AMP + 2 phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	O35795	-	-
Rattus norvegicus	P97687	-	-
Rattus norvegicus	Q5DRK1	-	-
Rattus norvegicus	Q80Z26	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + 2 H2O	-	Rattus norvegicus	AMP + 2 phosphate	-	?

Synonyms

Synonyms	Comment	Organism
ectonucleoside triphosphate diphosphohydrolase 3	UniProt	Rattus norvegicus
ENTPD1	-	Rattus norvegicus
ENTPD2	-	Rattus norvegicus
ENTPD3	-	Rattus norvegicus
Entpd8	-	Rattus norvegicus
esctonucleoside triphosphate diphosphohydrolase 1	UniProt	Rattus norvegicus
esctonucleoside triphosphate diphosphohydrolase 2	UniProt	Rattus norvegicus
esctonucleoside triphosphate diphosphohydrolase 8	UniProt	Rattus norvegicus
NTPDase	-	Rattus norvegicus
NTPDase 1	-	Rattus norvegicus
NTPDase 2	-	Rattus norvegicus
NTPDase 3	-	Rattus norvegicus
NTPDase 8	-	Rattus norvegicus
nucleoside triphosphate diphosphohydrolase	-	Rattus norvegicus
r-NTPDase 1	-	Rattus norvegicus
r-NTPDase 2	-	Rattus norvegicus
r-NTPDase 3	-	Rattus norvegicus
r-NTPDase 8	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Rattus norvegicus