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Literature summary for 3.6.1.5 extracted from

  • Fausther, M.; Lecka, J.; Soliman, E.; Kauffenstein, G.; Pelletier, J.; Sheung, N.; Dranoff, J.; Sevigny, J.
    Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver (2012), Am. J. Physiol. Gastrointest. Liver Physiol., 302, 447-459.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.5

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Rattus norvegicus 5886
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Rattus norvegicus
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Rattus norvegicus
-
 AMP + phosphate
-
 ?
ADP + H2O Rattus norvegicus Sprague-Dawley
-
 AMP + phosphate
-
 ?
ATP + 2 H2O Rattus norvegicus
-
 AMP + 2 phosphate
-
 ?
ATP + 2 H2O Rattus norvegicus Sprague-Dawley
-
 AMP + 2 phosphate
-
 ?
ATP + H2O Rattus norvegicus ATP incubated with NTPDase2 is readily converted into ADP, but very poorly into AMP ADP + phosphate
-
 ?
ATP + H2O Rattus norvegicus Sprague-Dawley ATP incubated with NTPDase2 is readily converted into ADP, but very poorly into AMP ADP + phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus O35795 NTPDase2
-
Rattus norvegicus P97687 NTPDase1
-
Rattus norvegicus Q5DRK1 NTPDase8
-
Rattus norvegicus Sprague-Dawley O35795 NTPDase2
-
Rattus norvegicus Sprague-Dawley P97687 NTPDase1
-
Rattus norvegicus Sprague-Dawley Q5DRK1 NTPDase8
-

Source Tissue

Source Tissue Comment Organism Textmining
bile canaliculus
-
 Rattus norvegicus
-
fibroblast
-
 Rattus norvegicus
-
fibroblast portal fibroblasts Rattus norvegicus
-
hepatocyte restricted to the canalicular membrane domain of hepatocytes Rattus norvegicus
-
liver expression of isozymes NTPDase1, -2, and -8 in distinct liver compartments in normal and fibrotic rat liver Rattus norvegicus
-
additional information enzyme tissue localization by in situ immunohistochemistry, overview Rattus norvegicus
-
smooth muscle cell
-
 Rattus norvegicus
-
vascular endothelial cell
-
 Rattus norvegicus
-
vascular system cells in the vascular external layer Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
 Rattus norvegicus AMP + phosphate
-
 ?
ADP + H2O
-
 Rattus norvegicus Sprague-Dawley AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Rattus norvegicus AMP + 2 phosphate
-
 ?
ATP + 2 H2O sequential dephosphorylation of ATP to ADP and then AMP Rattus norvegicus AMP + 2 phosphate
-
 ?
ATP + 2 H2O
-
 Rattus norvegicus Sprague-Dawley AMP + 2 phosphate
-
 ?
ATP + 2 H2O sequential dephosphorylation of ATP to ADP and then AMP Rattus norvegicus Sprague-Dawley AMP + 2 phosphate
-
 ?
ATP + H2O ATP incubated with NTPDase2 is readily converted into ADP, but very poorly into AMP Rattus norvegicus ADP + phosphate
-
 ?
ATP + H2O ATP incubated with NTPDase2 is readily converted into ADP, but very poorly into AMP Rattus norvegicus Sprague-Dawley ADP + phosphate
-
 ?

Synonyms

Synonyms Comment Organism
ATPase
-
 Rattus norvegicus
CD39
-
 Rattus norvegicus
CD39L1
-
 Rattus norvegicus
NTPDase1
-
 Rattus norvegicus
NTPDase1/CD39
-
 Rattus norvegicus
NTPDase2
-
 Rattus norvegicus
NTPDase2/CD39L1
-
 Rattus norvegicus
NTPDase8
-
 Rattus norvegicus
nucleoside triphosphate diphosphohydrolase
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus

General Information

General Information Comment Organism
metabolism plasma membrane-bound NTPDases, namely NTPDase1/CD39, NTPDase2/CD39L1, and NTPDase8, represent the major liver ectonucleotidase activities Rattus norvegicus