Literature summary for 3.6.1.5 extracted from

Coimbra, E.S.; Goncalves-da-Costa, S.C.; Corte-Real, S.; De Freitas, F.G.; Durao, A.C.; Souza, C.S.; Silva-Santos, M.I.; Vasconcelos, E.G.
Characterization and cytochemical localization of an ATP diphosphohydrolase from Leishmania amazonensis promastigotes (2002), Parasitology, 124, 137-143.

Search for more literature for 3.6.1.5

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	not inhibitory: vanadate, ouabain, thapsigargin, dicyclohexylcarbodiimide, oligomycin, bafilomycin A, levamisole, ammonium molybdate	Leishmania amazonensis
Sodium azide	-	Leishmania amazonensis

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
plasma membrane	-	Leishmania amazonensis	5886	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	best activating kation	Leishmania amazonensis
Co2+	at 1 mM, 73% of ATPase activity compared to Ca2+	Leishmania amazonensis
Mg2+	at 1 mM, 61% of ATPase activity compared to Ca2+	Leishmania amazonensis
Mn2+	at 1 mM, 65% of ATPase activity compared to Ca2+	Leishmania amazonensis
Zn2+	at 1 mM, 70% of ATPase activity compared to Ca2+	Leishmania amazonensis

Organism

Organism	UniProt	Comment	Textmining
Leishmania amazonensis	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
promastigote	surface and flagellar pocket	Leishmania amazonensis	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5'-AMP + H2O	23% of activity compared to ATP	Leishmania amazonensis	adenosine + phosphate	-	?
ADP + H2O	104% of activity compared to ATP	Leishmania amazonensis	AMP + phosphate	-	?
ATP + 2 H2O	-	Leishmania amazonensis	AMP + 2 phosphate	-	?
CTP + 2 H2O	60% of activity compared to ATP	Leishmania amazonensis	CMP + 2 phosphate	-	?
GTP + 2 H2O	23% of activity compared to ATP	Leishmania amazonensis	GMP + 2 phosphate	-	?
UTP + 2 H2O	150% of activity compared to ATP	Leishmania amazonensis	UMP + 2 phosphate	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)