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Literature summary for 3.6.1.5 extracted from

  • de Aguiar Matos, J.A.; Borges, F.P.; Tasca, T.; Bogo, M.R.; De Carli, G.A.; da Graca Fauth, M.; Dias, R.D.; Bonan, C.D.
    Characterisation of an ATP diphosphohydrolase (Apyrase, EC 3.6.1.5) activity in Trichomonas vaginalis (2001), Int. J. Parasitol., 31, 770-775.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
additional information not inhibitory: ouabain, N-ethylmaleimide, orthovanadate, levamisole, P1,P5-di(adenosine 5’)pentaphosphate Trichomonas vaginalis
Sodium azide not inhibitory at 5 mM, up to 37% inhibition at 20 mM Trichomonas vaginalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.049
-
 ATP pH 7.2, 37°C Trichomonas vaginalis
0.05
-
 ADP pH 7.2, 37°C Trichomonas vaginalis

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required Trichomonas vaginalis

Organism

Organism UniProt Comment Textmining
Trichomonas vaginalis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O 119% of activity compared to ATP Trichomonas vaginalis AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Trichomonas vaginalis AMP + 2 phosphate
-
 ?
ITP + 2 H2O 109% of activity compared to ATP Trichomonas vaginalis IMP + 2 phosphate
-
 ?
UDP + H2O 104% of activity compared to ATP Trichomonas vaginalis UMP + phosphate
-
 ?

pH Range

pH Minimum pH Maximum Comment Organism
6 8
-
 Trichomonas vaginalis