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Literature summary for 3.6.1.5 extracted from

  • Kettlun, A.M.; Alvarez, A.; Quintar, R.; Valenzuela, M.A.; Collados, L.; Aranda, E.; Banda, A.; Chayet, L.; Chiong, M.; Mancilla, M.; Traverso-Cori, A.
    Human placental ATP-diphosphohydrolase: biochemical characterization, regulation and function (1994), Int. J. Biochem., 26, 437-448.
    View publication on PubMed

General Stability

General Stability Organism
inactivated by Tween 20 Homo sapiens
unstable to detergent Triton X-100 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CDTA
-
Homo sapiens
dicylcohexylcarbodiimid DCCD, slightly inhibited Homo sapiens
EDTA
-
Homo sapiens
EGTA
-
Homo sapiens
additional information no inhibition by Ap5A; no inhibition by ouabain Homo sapiens
orthovanadate
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane membrane-bound Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ maximum activity at 0.5 mM Homo sapiens
Ca2+ Ca2+ preferred to Mg2+ Homo sapiens
Mg2+ Mg2+ preferred to Mn2+ Homo sapiens
Mn2+ preferred to Zn2+ Homo sapiens
Zn2+ preferred to Co2+ Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
60500
-
radiation-inactivation, ADPase Homo sapiens
62700
-
radiation-inactivation, ATPase Homo sapiens
64000
-
SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Homo sapiens
-
AMP + phosphate
-
?
ATP + 2 H2O Homo sapiens inhibition of platelet aggregation in the placenta AMP + 2 phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein interaction with concanavalin-A Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Storage Stability

Storage Stability Organism
4°C, octylglucoside, stable Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
Homo sapiens AMP + phosphate
-
?
ATP + 2 H2O
-
Homo sapiens AMP + 2 phosphate
-
?
ATP + 2 H2O inhibition of platelet aggregation in the placenta Homo sapiens AMP + 2 phosphate
-
?
CDP + H2O
-
Homo sapiens CMP + phosphate
-
?
CTP + 2 H2O
-
Homo sapiens CMP + 2 phosphate
-
?
GDP + H2O
-
Homo sapiens GMP + phosphate
-
?
GTP + 2 H2O
-
Homo sapiens GMP + 2 phosphate
-
?
TDP + H2O
-
Homo sapiens TMP + phosphate
-
?
TTP + 2 H2O
-
Homo sapiens TMP + 2 phosphate
-
?
UDP + H2O
-
Homo sapiens UMP + phosphate
-
?
UTP + 2 H2O
-
Homo sapiens UMP + 2 phosphate
-
?