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Literature summary for 3.6.1.5 extracted from

  • Frassetto, S.S.; Dias, R.D.; Sarkis, J.J.
    Inhibition and kinetic alterations by excess free ATP and ADP of the ATP disphosphohydrolase activity (EC 3.6.1.5) from rat blood platelets (1995), Biochem. Mol. Biol. Int., 35, 499-506.
    View publication on PubMed
Search for more literature for 3.6.1.5

Inhibitors

Inhibitors Comment Organism Structure
ADP hydrolysis of CaATP2- and CaADP- decreased by 50% at 0.48 mM free ADP Rattus norvegicus
ATP hydrolysis of CaATP2- and CaADP- decreased by 50% at 0.3 mM free ATP Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.024
-
 ATP CaATP2- Rattus norvegicus
0.025
-
 ATP free ATP Rattus norvegicus
0.031
-
 ADP CaADP- Rattus norvegicus
0.042
-
 ADP free ADP Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ required for activity Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + H2O Rattus norvegicus
-
 AMP + phosphate
-
 ?
ATP + 2 H2O Rattus norvegicus
-
 AMP + 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 rat
-

Source Tissue

Source Tissue Comment Organism Textmining
blood platelet
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.004
-
 ADP, presence of Ca2+ Rattus norvegicus
0.007
-
 ATP, presence of Ca2+ Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
 Rattus norvegicus AMP + phosphate
-
 ?
ADP + H2O as CaADP- only Rattus norvegicus AMP + phosphate
-
 ?
ATP + 2 H2O
-
 Rattus norvegicus AMP + 2 phosphate
-
 ?
ATP + 2 H2O as CaATP2- only Rattus norvegicus AMP + 2 phosphate
-
 ?