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Literature summary for 3.6.1.29 extracted from

  • Martin, J.; St-Pierre, M.V.; Dufour, J.F.
    Hit proteins, mitochondria and cancer (2011), Biochim. Biophys. Acta, 1807, 626-632.
    View publication on PubMed
Search for more literature for 3.6.1.29

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P49789
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein FHIT is phosphorylated at Tyr114 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Ap3A + H2O
-
 Homo sapiens ADP + AMP
-
 ?

Synonyms

Synonyms Comment Organism
Fhit
-
 Homo sapiens
fragile histidine triad
-
 Homo sapiens
fragile HIT protein
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens FHIT is absent or reduced in many types of human tumors including lung, esophagus, stomach, kidney and cervical carcinomas down

General Information

General Information Comment Organism
malfunction a loss of FHIT expression associated with poor prognosis and beta-catenin expression Homo sapiens
physiological function the FHIT protein is a tumor suppressor. FHIT/ferrodoxin reductase complex generates reactive oxygen species and increases calcium uptake into the mitochondria to potentiate the effects of apoptotic agents Homo sapiens