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Literature summary for 3.6.1.29 extracted from

  • Banerjee, H.; Palenchar, J.B.; Lukaszewicz, M.; Bojarska, E.; Stepinski, J.; Jemielity, J.; Guranowski, A.; Ng, S.; Wah, D.A.; Darzynkiewicz, E.; Bellofatto, V.
    Identification of the HIT-45 protein from Trypanosoma brucei as an FHIT protein/dinucleoside triphosphatase: substrate specificity studies on the recombinant and endogenous proteins (2009), RNA, 15, 1554-1564.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.6.1.29

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Trypanosoma brucei

Protein Variants

Protein Variants Comment Organism
H355N inactive Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-
Trypanosoma brucei 427
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose column chromatography Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GpppA + H2O
-
 Trypanosoma brucei GMP + ADP + GDP + AMP
-
 ?
GpppA + H2O
-
 Trypanosoma brucei 427 GMP + ADP + GDP + AMP
-
 ?
m27,2'OGpppG + H2O
-
 Trypanosoma brucei ppm27,2'OG + guanosine monophosphate
-
 ?
m27,2'OGpppG + H2O
-
 Trypanosoma brucei 427 ppm27,2'OG + guanosine monophosphate
-
 ?
m2N2,7GpppG + H2O
-
 Trypanosoma brucei pm2N2,7G + guanosine diphosphate
-
 ?
m3N2,N2,7GpppA + H2O
-
 Trypanosoma brucei ppm3N2,N2,7G + adenosine monophosphate
-
 ?
m3N2,N2,7GpppG + H2O
-
 Trypanosoma brucei ppm3N2,N2,7G + guanosine monophosphate
-
 ?
m7GpppA + H2O
-
 Trypanosoma brucei N7-methyl-GMP + ADP + N7-methyl-GDP + AMP
-
 ?
m7GpppG + H2O
-
 Trypanosoma brucei pm7G + guanosine diphosphate
-
 ?
m7Gpppm3N6,N6,2'OA + H2O
-
 Trypanosoma brucei pm7G + ppm3N6,N6,2'OA
-
 ?
m7Gpppm7G + H2O
-
 Trypanosoma brucei N7-methyl-GMP + N7-methyl-GDP
-
 ?
m7GpppmN6A + H2O
-
 Trypanosoma brucei pm7G + ppmN6A
-
 ?
additional information the enzyme does not hydrolyze Cap 4 m7Gpppm3N6,N6,2'O, Apm2'OApm2'OCpm2N3,2'OU, m7GpppApApCpU, m7GpCH2ppG, and m7Gpppm3N6,N6,2'OApm29OA Trypanosoma brucei ?
-
 ?
additional information the enzyme does not hydrolyze Cap 4 m7Gpppm3N6,N6,2'O, Apm2'OApm2'OCpm2N3,2'OU, m7GpppApApCpU, m7GpCH2ppG, and m7Gpppm3N6,N6,2'OApm29OA Trypanosoma brucei 427 ?
-
 ?
P1-P3-bis(5'-adenosyl) triphosphate + H2O highest specificity Trypanosoma brucei ADP + AMP
-
 ?
P1-P3-bis(5'-adenosyl) triphosphate + H2O highest specificity Trypanosoma brucei 427 ADP + AMP
-
 ?
P1-P3-bis(5'-guanosyl) triphosphate + H2O
-
 Trypanosoma brucei GDP + GMP
-
 ?
P1-P3-bis(5'-guanosyl) triphosphate + H2O
-
 Trypanosoma brucei 427 GDP + GMP
-
 ?
P1-P5-bis(5'-adenosyl) pentaphosphate + H2O
-
 Trypanosoma brucei adenosine monophosphate + adenosine tetraphosphate
-
 ?

Synonyms

Synonyms Comment Organism
FHIT protein/dinucleoside triphosphatase
-
 Trypanosoma brucei
HIT-45 protein
-
 Trypanosoma brucei