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Literature summary for 3.6.1.27 extracted from

  • Gasiorowski, E.; Auger, R.; Tian, X.; Hicham, S.; Ecobichon, C.; Roure, S.; Douglass, M.V.; Trent, M.S.; Mengin-Lecreulx, D.; Touze, T.; Boneca, I.G.
    HupA, the main undecaprenyl pyrophosphate and phosphatidylglycerol phosphate phosphatase in Helicobacter pylori is essential for colonization of the stomach (2019), PLoS Pathog., 15, e1007972 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli C43(DE3) cells Helicobacter pylori

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Helicobacter pylori 16020
-

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Helicobacter pylori N6
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA agarose bead chromatography Helicobacter pylori

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.958
-
with phosphatidylglycerol phosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori
6.019
-
with isopentenyl diphosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori
6.039
-
with undecaprenyl diphosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori
24.084
-
with diacylglycerol diphosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori
160.406
-
with farnesyl diphosphate as substrate, at pH 7.4 and 37°C Helicobacter pylori

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
diacylglycerol diphosphate + H2O
-
Helicobacter pylori diacylglycerol phosphate + phosphate
-
?
diacylglycerol diphosphate + H2O
-
Helicobacter pylori N6 diacylglycerol phosphate + phosphate
-
?
farnesyl diphosphate + H2O
-
Helicobacter pylori farnesyl phosphate + phosphate
-
?
farnesyl diphosphate + H2O
-
Helicobacter pylori N6 farnesyl phosphate + phosphate
-
?
isopentenyl diphosphate + H2O
-
Helicobacter pylori isopentenyl phosphate + phosphate
-
?
isopentenyl diphosphate + H2O
-
Helicobacter pylori N6 isopentenyl phosphate + phosphate
-
?
additional information no activity with phosphatidic acid Helicobacter pylori ?
-
-
additional information no activity with phosphatidic acid Helicobacter pylori N6 ?
-
-
phosphatidylglycerol phosphate + H2O
-
Helicobacter pylori phosphatidylglycerol + phosphate
-
?
phosphatidylglycerol phosphate + H2O
-
Helicobacter pylori N6 phosphatidylglycerol + phosphate
-
?

Subunits

Subunits Comment Organism
? x * 25800, SDS-PAGE Helicobacter pylori

Synonyms

Synonyms Comment Organism
C55-PP pyrophosphatase
-
Helicobacter pylori
HP0851
-
Helicobacter pylori
HupA
-
Helicobacter pylori
undecaprenyl pyrophosphate phosphatase
-
Helicobacter pylori
UppP
-
Helicobacter pylori

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
-
Helicobacter pylori

General Information

General Information Comment Organism
physiological function the enzyme is essential in vivo for stomach colonization and is also involved in cationic antimicrobial peptide resistance Helicobacter pylori