Literature summary for 3.6.1.27 extracted from

Shaaly, A.; Kalamorz, F.; Gebhard, S.; Cook, G.M.
Undecaprenyl pyrophosphate phosphatase confers low-level resistance to bacitracin in Enterococcus faecalis (2013), J. Antimicrob. Chemother., 68, 1583-1593.

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Organism

Organism	UniProt	Comment	Textmining
Enterococcus faecalis	Q5WNX2	-	-

Expression

Organism	Comment	Expression
Enterococcus faecalis	expression of is constitutive and not affected by bacitracin or cell wall-active antimicrobials	additional information

General Information

General Information	Comment	Organism
physiological function	mutants lacking enzymic activity show no significant changes in growth rate, colony morphology and biofilm formation. The mutants exhibit increased susceptibility to bacitracin. When the enzyme is expressed in a wild-type background, the minimum inhibitory concentration of bacitracin increases to 256 mg/L. The minimum inhibitory concentrations of cefoxitin, teicoplanin, vancomycin, gentamicin, enrofloxacin and D-cycloserine are unaltered in the mutant relative to the wild-type, as are susceptibilities to other stress agents such as glycine, lysozyme, NaCl, SDS, low and high pH, oxidative stress and ethanol	Enterococcus faecalis

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Release 2023.1 (January 2023)