Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of chromosomal gene deletions mutants, double and triple deletion mutants in the genes uppP and ybjG, and uppP, ybjG and yeiU, respectively, are supersensitive to the Und-P de novo biosynthesis inhibitor fosmidomycin, while single or combined deletions including pgpB have no effect on fosmidomycin supersensitivity, overview | Escherichia coli |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | UppP and UppS exert their enzymic activity on the cytoplasmic side of the plasma membrane | Escherichia coli | 5737 | - |
periplasm | YbjG and, to a lesser extent, YeiU exert their enzymic activity on the periplasmic side of the plasma membrane | Escherichia coli | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
undecaprenyl diphosphate + H2O | Escherichia coli | the dephosphorylation of Und-PP, from de novo synthesis, produces undecaprenyl phosphate, a universal lipid carrier of glycan biosynthetic intermediates for carbohydrate polymers that are exported to the bacterial cell envelope, YbjG and YeiU are implicated in the recycling of periplasmic Und-PP molecules | undecaprenyl phosphate + phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
genes uppP, ybjG, and yeiU | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | UppP accounts for 75% of the total cellular Und-PP pyrophosphatase activity | Escherichia coli | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
undecaprenyl diphosphate + H2O | - |
Escherichia coli | undecaprenyl phosphate + phosphate | - |
? | |
undecaprenyl diphosphate + H2O | the dephosphorylation of Und-PP, from de novo synthesis, produces undecaprenyl phosphate, a universal lipid carrier of glycan biosynthetic intermediates for carbohydrate polymers that are exported to the bacterial cell envelope, YbjG and YeiU are implicated in the recycling of periplasmic Und-PP molecules | Escherichia coli | undecaprenyl phosphate + phosphate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
undecaprenyl-pyrophosphate phosphatase | - |
Escherichia coli |
UppP | formerly BacA | Escherichia coli |
YbjG | - |
Escherichia coli |
YeiU | - |
Escherichia coli |