Literature summary for 3.6.1.23 extracted from

Nyiri, K.; Mertens, H.D.T.; Tihanyi, B.; Nagy, G.N.; Kohegyi, B.; Matejka, J.; Harris, M.J.; Szabo, J.E.; Papp-Kadar, V.; Nemeth-Pongracz, V.; Ozohanics, O.; Vekey, K.; Svergun, D.I.; Borysik, A.J.; Vertessy, B.G.
Structural model of human dUTPase in complex with a novel proteinaceous inhibitor (2018), Sci. Rep., 8, 4326 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) Rosetta cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
staphylococcal repressor protein StlSaPIBov1	highly potent inhibitor	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
54100	-	calculated from amino acid sequence	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
dUTP + H2O	Homo sapiens	-	dUMP + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
dUTP + H2O	-	Homo sapiens	dUMP + diphosphate	-	?

Subunits

Subunits	Comment	Organism
trimer	-	Homo sapiens

Synonyms

Synonyms	Comment	Organism
deoxyuridine 5'-triphosphate nucleotidohydrolase	-	Homo sapiens
DUT	-	Homo sapiens
dUTPase	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0000067	-	staphylococcal repressor protein StlSaPIBov1	at pH 7.5 and 20°C	Homo sapiens

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Release 2023.1 (January 2023)