Organism | UniProt | Comment | Textmining |
---|---|---|---|
Human alphaherpesvirus 2 | - |
- |
- |
Human alphaherpesvirus 3 | - |
- |
- |
Human betaherpesvirus 6A | P30007 | - |
- |
Human betaherpesvirus 6A GS | P30007 | - |
- |
Human gammaherpesvirus 8 | P88942 | - |
- |
Human gammaherpesvirus 8 type M | P88942 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
ORF 54 | - |
Human gammaherpesvirus 8 |
ORF8 | - |
Human alphaherpesvirus 3 |
U45 | - |
Human betaherpesvirus 6A |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme activates nuclear factor NF-kappaB through ligation of TLR2/TLR1 heterodimers. Activation of NF-kappaB is inhibited by anti-TLR2 blocking antibodies and the overexpression of dominant-negative constructs of TLR2, lacking the TIR domain, and MyD88 in human embryonic kidney 293 cells expressing TLR2/TLR1. Treatment of human dendritic cells and peripheral blood mononuclear cells with the dUTPases results in the secretion of the inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, IL-10, and IFN-gamma | Human alphaherpesvirus 2 |
physiological function | enzyme activates nuclear factor NF-kappaB through ligation of TLR2/TLR1 heterodimers. Activation of NF-kappaB is inhibited by anti-TLR2 blocking antibodies and the overexpression of dominant-negative constructs of TLR2, lacking the TIR domain, and MyD88 in human embryonic kidney 293 cells expressing TLR2/TLR1. Treatment of human dendritic cells and peripheral blood mononuclear cells with the dUTPases results in the secretion of the inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, IL-10, and IFN-gamma | Human alphaherpesvirus 3 |
physiological function | enzyme activates nuclear factor NF-kappaB through ligation of TLR2/TLR1 heterodimers. Activation of NF-kappaB is inhibited by anti-TLR2 blocking antibodies and the overexpression of dominant-negative constructs of TLR2, lacking the TIR domain, and MyD88 in human embryonic kidney 293 cells expressing TLR2/TLR1. Treatment of human dendritic cells and peripheral blood mononuclear cells with the dUTPases results in the secretion of the inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, IL-10, and IFN-gamma | Human betaherpesvirus 6A |
physiological function | enzyme activates nuclear factor NF-kappaB through ligation of TLR2/TLR1 heterodimers. Activation of NF-kappaB is inhibited by anti-TLR2 blocking antibodies and the overexpression of dominant-negative constructs of TLR2, lacking the TIR domain, and MyD88 in human embryonic kidney 293 cells expressing TLR2/TLR1. Treatment of human dendritic cells and peripheral blood mononuclear cells with the dUTPases results in the secretion of the inflammatory cytokines IL-1beta, IL-6, IL-8, IL-12, TNF-alpha, IL-10, and IFN-gamma | Human gammaherpesvirus 8 |