Literature summary for 3.6.1.23 extracted from

Ariza, M.E.; Glaser, R.; Kaumaya, P.T.; Jones, C.; Williams, M.V.
The EBV-encoded dUTPase activates NF-kappa B through the TLR2 and MyD88-dependent signaling pathway (2009), J. Immunol., 182, 851-859.

Search for more literature for 3.6.1.23

Application

Application	Comment	Organism
drug development	the enzyme is a target for development of therapeutic drugs against EBV infection	Human gammaherpesvirus 4

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Human gammaherpesvirus 4	the enzyme has immunomodulatory function in pathogenesis, treatment of human monocyte-derived macrophages with dUTPase from Ebstein-Barr virus induces the expression of proinflammatory cytokines, e.g. interleukin-6, through activation of NF-kappaB via TLR2 receptor, but not TLR3 or TLR4, requiring the adaptor molecule MyD88, but not CD14, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Human gammaherpesvirus 4	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
native enzyme from virus	Human gammaherpesvirus 4

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	the enzyme has immunomodulatory function in pathogenesis, treatment of human monocyte-derived macrophages with dUTPase from Ebstein-Barr virus induces the expression of proinflammatory cytokines, e.g. interleukin-6, through activation of NF-kappaB via TLR2 receptor, but not TLR3 or TLR4, requiring the adaptor molecule MyD88, but not CD14, overview	Human gammaherpesvirus 4	?	-	?

Synonyms

Synonyms	Comment	Organism
dUTPase	-	Human gammaherpesvirus 4

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Release 2023.1 (January 2023)