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Literature summary for 3.6.1.23 extracted from

  • Muha, V.; Zagyva, I.; Venkei, Z.; Szabad, J.; Vertessy, B.G.
    Nuclear localization signal-dependent and -independent movements of Drosophila melanogaster dUTPase isoforms during nuclear cleavage (2009), Biochem. Biophys. Res. Commun., 381, 271-275.
    View publication on PubMed
Search for more literature for 3.6.1.23

Cloned(Commentary)

Cloned (Comment) Organism
expression in Schneider 2 cells Drosophila melanogaster

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm 21 kDa isozyme, the 21 kDa isozyme is excluded from the nuclei during interphase, it is shifted to the nucleus during prophase and forthcoming mitotic steps Drosophila melanogaster 5737
-
additional information both isoforms can be present within the nuclear microenvironment, although at different stages of cell cycle by strict timing to the nuclear cleavage phases Drosophila melanogaster
-
-
nucleus 23 kDa isozyme, the 21 kDa isozyme is excluded from the nuclei during interphase, it is shifted to the nucleus during prophase and forthcoming mitotic steps Drosophila melanogaster 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21000
-
 x * 21000, isozyme 1, SDS-PAGE, x * 23000, isozyme 2, SDS-PAGE Drosophila melanogaster
23000
-
 x * 21000, isozyme 1, SDS-PAGE, x * 23000, isozyme 2, SDS-PAGE Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Drosophila melanogaster an efficient preventive repair pathway, avoiding uracil in DNA, is generally present that keeps cellular dUTP/dTTP levels at a much decreased value to prevent use of dUTP as a building block by DNA polymerases. The enzyme responsible for this sanitizing role is dUTPase, a ubiquitous protein dUMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
 two dUTPase isozymes
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo at the syncytial blastoderm stage, localization shifts of dUTPase isozymes within embryos, overview Drosophila melanogaster
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
 Drosophila melanogaster dUMP + diphosphate
-
 ?
dUTP + H2O an efficient preventive repair pathway, avoiding uracil in DNA, is generally present that keeps cellular dUTP/dTTP levels at a much decreased value to prevent use of dUTP as a building block by DNA polymerases. The enzyme responsible for this sanitizing role is dUTPase, a ubiquitous protein Drosophila melanogaster dUMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
? x * 21000, isozyme 1, SDS-PAGE, x * 23000, isozyme 2, SDS-PAGE Drosophila melanogaster

Synonyms

Synonyms Comment Organism
dUTPase
-
 Drosophila melanogaster