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Literature summary for 3.6.1.23 extracted from

  • Studebaker, A.W.; Lafuse, W.P.; Kloesel, R.; Williams, M.V.
    Modulation of human dUTPase using small interfering RNA (2005), Biochem. Biophys. Res. Commun., 327, 306-310.
    View publication on PubMed
Search for more literature for 3.6.1.23

Application

Application Comment Organism
drug development the enzyme might be a target for drug development Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
siRNAdUT3 a 21 base-pair double-stranded RNA molecule targeted against the motif 3 of the enzyme, time- and dose-dependent decrease in the dUTPase activity in transfected cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Homo sapiens
-
 dUMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P33316 gene DUT; gene DUT
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
SW-620 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUTP + H2O
-
 Homo sapiens dUMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
deoxyuridine 5'-triphosphate nucleotidohydrolase
-
 Homo sapiens
deoxyuridine triphosphate nucleotidohydrolase
-
 Homo sapiens
dUTP pyrophosphatase
-
 Homo sapiens
dUTPase
-
 Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens