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Literature summary for 3.6.1.23 extracted from

  • Harkiolaki, M.; Dodson, E.J.; Bernier-Villamor, V.; Turkenburg, J.P.; Gonzalez-Pacanowska, D.; Wilson, K.S.
    The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold (2004), Structure, 12, 41-53.
    View publication on PubMed
Search for more literature for 3.6.1.23

Application

Application Comment Organism
medicine potential target for treatment of Chagas' disease Trypanosoma cruzi

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) Trypanosoma cruzi

Crystallization (Commentary)

Crystallization (Comment) Organism
vapor diffusion method Trypanosoma cruzi

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dUTP + H2O Trypanosoma cruzi removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA dUMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dUDP + H2O
-
 Trypanosoma cruzi dUMP + phosphate
-
 ?
dUTP + H2O
-
 Trypanosoma cruzi dUMP + diphosphate
-
 ?
dUTP + H2O removes dUTP from the nucleotide triphosphate pool and therefore prevents the incorporation of uracil into the DNA Trypanosoma cruzi dUMP + diphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer two identical subunits, crystal structure analysis Trypanosoma cruzi