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Literature summary for 3.6.1.23 extracted from

  • Bergman, A.C.; Nyman, P.O.; Larsson, G.
    Kinetic properties and stereospecificity of the monomeric dUTPase from herpes simplex virus type 1 (1998), FEBS Lett., 441, 327-330.
    View publication on PubMed
Search for more literature for 3.6.1.23

Inhibitors

Inhibitors Comment Organism Structure
dCTP
-
 Human alphaherpesvirus 1
dTTP
-
 Human alphaherpesvirus 1
dUDP
-
 Human alphaherpesvirus 1
dUMP alphaS
-
 Human alphaherpesvirus 1
dUTPalphaS
-
 Human alphaherpesvirus 1
UDP
-
 Human alphaherpesvirus 1
Uracil
-
 Human alphaherpesvirus 1

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0002
-
 dUTPalphaS
-
 Human alphaherpesvirus 1
0.0003
-
 dUTP
-
 Human alphaherpesvirus 1
0.4
-
 dTTP
-
 Human alphaherpesvirus 1
1
-
 UTP
-
 Human alphaherpesvirus 1
1
-
 dCTP
-
 Human alphaherpesvirus 1

Organism

Organism UniProt Comment Textmining
Human alphaherpesvirus 1
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dCTP + H2O
-
 Human alphaherpesvirus 1 dCMP + diphosphate
-
 ?
dTTP + H2O
-
 Human alphaherpesvirus 1 dTMP + diphosphate
-
 ?
dUTP + H2O
-
 Human alphaherpesvirus 1 dUMP + diphosphate
-
 ?
dUTPalphaS + H2O
-
 Human alphaherpesvirus 1 dUMP + thiodiphosphate
-
 ?
UTP + H2O
-
 Human alphaherpesvirus 1 UMP + diphosphate
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5 15 dUTP
-
 Human alphaherpesvirus 1

pH Stability

pH Stability pH Stability Maximum Comment Organism
6 9 stable for several h Human alphaherpesvirus 1