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Literature summary for 3.6.1.22 extracted from

  • Nakajima, Y.; Fukunaga, N.; Sasaki, S.; Usami, S.
    Purification and properties of NADP pyrophosphatase from Proteus vulgaris (1973), Biochim. Biophys. Acta, 293, 242-255.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2',5'-ADP 44% inhibition at concentration of 0.133 mM Proteus vulgaris
ADP 21% inhibition at concentration of 0.133 mM Proteus vulgaris
ATP 22% inhibition at concentration of 0.066 mM Proteus vulgaris
Ca2+ 20% inhibition at concentration of 0.33 mM Proteus vulgaris
Co2+ 40% inhibition of the purified enzyme at concentration of 0.33 mM, activity in crude extract not affected Proteus vulgaris
CoA 85% inhibition at concentration of 0.133 mM Proteus vulgaris
CTP 55% inhibition at concentration of 0.066 mM Proteus vulgaris
DNA strong inhibition by denaturated DNA, slight inhibition by native DNA Proteus vulgaris
EDTA 87% inhibition, reactivation by Mn2+ or Co2+ Proteus vulgaris
FAD 35% inhibition at concentration of 0.133 mM Proteus vulgaris
GTP 53% inhibition at concentration of 0.066 mM Proteus vulgaris
RNA strong inhibition Proteus vulgaris
UDP 32% inhibition at concentration of 0.133 mM Proteus vulgaris
UTP 36% inhibition at concentration of 0.066 mM Proteus vulgaris
Zn2+ 70% inhibition at concentration of 0.33 mM Proteus vulgaris

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
NADP+ Tris-HCl, pH 7.0 Proteus vulgaris

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ reactivation of EDTA-treated enzyme Proteus vulgaris
Mg2+ slight activation at concentration of 1.0 mM Proteus vulgaris
Mn2+ slight activation at concentration of 1.0 mM, reactivation of EDTA-treated enzyme Proteus vulgaris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADP+ + H2O Proteus vulgaris possible function in regulation of NADP-level NMN + adenosine 3',5'-diphosphate
-
?

Organism

Organism UniProt Comment Textmining
Proteus vulgaris
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Proteus vulgaris

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0008
-
crude extract Proteus vulgaris
0.78
-
purified enzyme with 1 mM MnCl2 Proteus vulgaris

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + H2O
-
Proteus vulgaris AMP + phosphate
-
?
AMP + H2O
-
Proteus vulgaris adenosine + phosphate
-
?
NAD+ + H2O
-
Proteus vulgaris NMN + AMP
-
ir
NADH + H2O
-
Proteus vulgaris AMP + NMNH
-
?
NADP+ + H2O
-
Proteus vulgaris NMN + adenosine 3',5'-diphosphate
-
?
NADP+ + H2O possible function in regulation of NADP-level Proteus vulgaris NMN + adenosine 3',5'-diphosphate
-
?
NADPH + H2O
-
Proteus vulgaris ?
-
?
UDP + H2O
-
Proteus vulgaris UMP + phosphate
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Proteus vulgaris