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Literature summary for 3.6.1.18 extracted from
- On the enzymatic hydrolysis of FAD in spinach leaves (1970), J. Vitaminol. (Kyoto), 16, 31-38.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenine | slight inhibition | Spinacia oleracea |  |
| adenosine | slight inhibition | Spinacia oleracea | |
| ADP | - |
Spinacia oleracea | |
| AMP | - |
Spinacia oleracea | |
| ATP | - |
Spinacia oleracea | |
| CMP | slight inhibition | Spinacia oleracea | |
| IMP | slight inhibition | Spinacia oleracea | |
| NAD+ | very effective inhibitor | Spinacia oleracea | |
| NADP+ | - |
Spinacia oleracea | |
| phosphate | e.g. KH2PO4 | Spinacia oleracea | |
| UMP | slight inhibition | Spinacia oleracea | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
FAD | - |
Spinacia oleracea | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ag2+ | strong inhibition | Spinacia oleracea | |
| Co2+ | slight activation | Spinacia oleracea | |
| Cu2+ | strong inhibition | Spinacia oleracea | |
| Hg2+ | strong inhibition | Spinacia oleracea | |
| Mn2+ | slight activation | Spinacia oleracea | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| FAD + H2O | Spinacia oleracea | - |
FMN + AMP | - |
ir | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Spinacia oleracea | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ADP + H2O | - |
Spinacia oleracea | AMP + phosphate | - |
? | |
| ATP + H2O | - |
Spinacia oleracea | ? | - |
? | |
| diphosphate + H2O | - |
Spinacia oleracea | 2 phosphate | - |
? | |
| FAD + H2O | - |
Spinacia oleracea | FMN + AMP | - |
ir | |
| NAD+ + H2O | - |
Spinacia oleracea | NMN + AMP | - |
? | |
| NADH + H2O | - |
Spinacia oleracea | NMNH + AMP | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
- |
Spinacia oleracea |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5 | - |
in presence of CdCl2 or EDTA | Spinacia oleracea |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 4 | 8 | 60% of maximum activity at pH 4, 20% of maximum activity at pH 8 | Spinacia oleracea |
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Release 2023.1 (January 2023)
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