Cloned (Comment) | Organism |
---|---|
expression in insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
T70A | active site mutant, has no effect on platelet aggregation and secretion | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y6X5 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
vascular endothelium | present on surface of vascular endothelium | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
P1,P3-bis(5'-adenosyl)triphosphate + H2O | - |
Homo sapiens | AMP + ADP | - |
? | |
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O | - |
Homo sapiens | AMP + ATP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ENPP4 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the primary and secondary waves of platelet aggregation and dense granule release are strongly induced by nanomolar ENPP4 in the presence of Ap3A, while Ap3A alone initiates a primary wave of aggregation followed by rapid disaggregation. ENPP4 mediates platelet aggregation via release of ADP from Ap3A and activation of ADP receptors | Homo sapiens |