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Literature summary for 3.6.1.17 extracted from

  • Albright, R.A.; Chang, W.C.; Robert, D.; Ornstein, D.L.; Cao, W.; Liu, L.; Redick, M.E.; Young, J.I.; De La Cruz, E.M.; Braddock, D.T.
    NPP4 is a procoagulant enzyme on the surface of vascular endothelium (2012), Blood, 120, 4432-4440.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
T70A active site mutant, has no effect on platelet aggregation and secretion Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y6X5
-
-

Source Tissue

Source Tissue Comment Organism Textmining
vascular endothelium present on surface of vascular endothelium Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
P1,P3-bis(5'-adenosyl)triphosphate + H2O
-
Homo sapiens AMP + ADP
-
?
P1,P4-bis(5'-adenosyl)tetraphosphate + H2O
-
Homo sapiens AMP + ATP
-
?

Synonyms

Synonyms Comment Organism
ENPP4
-
Homo sapiens

General Information

General Information Comment Organism
physiological function the primary and secondary waves of platelet aggregation and dense granule release are strongly induced by nanomolar ENPP4 in the presence of Ap3A, while Ap3A alone initiates a primary wave of aggregation followed by rapid disaggregation. ENPP4 mediates platelet aggregation via release of ADP from Ap3A and activation of ADP receptors Homo sapiens