Inhibitors | Comment | Organism | Structure |
---|---|---|---|
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A | competitive inhibitor | Homo sapiens | |
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A | competitive inhibitor | Lupinus angustifolius | |
A-5'-p-beta,beta'-methyleneoxy-p-5'-A | competitive inhibitor | Homo sapiens | |
A-5'-p-beta,beta'-methyleneoxy-p-5'-A | competitive inhibitor | Lupinus angustifolius |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
diadenosine 5',5'-P1,P4-tetraphosphate | - |
Homo sapiens | |
0.0025 | - |
diadenosine 5',5'-P1,P4-tetraphosphate | - |
Lupinus angustifolius |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | 5 mM MgCl2 included in assay medium | Homo sapiens | |
Mg2+ | 5 mM MgCl2 included in assay medium | Lupinus angustifolius |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
diadenosine 5',5'-P1,P4-tetraphosphate + H2O | Homo sapiens | - |
ATP + AMP | - |
? | |
diadenosine 5',5'-P1,P4-tetraphosphate + H2O | Lupinus angustifolius | - |
ATP + AMP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Lupinus angustifolius | - |
- |
- |
Purification (Comment) | Organism |
---|---|
symmetrical Ap4A hydrolase is partially purified from Escherichia coli | Lupinus angustifolius |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A + H2O | diadenosine polyphosphate analog | Homo sapiens | 2 alpha,beta-oxymethylene-ADP | - |
? | |
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A + H2O | diadenosine polyphosphate analog | Lupinus angustifolius | 2 alpha,beta-oxymethylene-ADP | - |
? | |
betabeta'-methyleneoxy-Ap4A + H2O | diadenosine polyphosphate analog | Homo sapiens | AMP + beta,gamma-methyleneoxy-ATP | - |
? | |
betabeta'-methyleneoxy-Ap4A + H2O | diadenosine polyphosphate analog | Lupinus angustifolius | AMP + beta,gamma-methyleneoxy-ATP | - |
? | |
diadenosine 5',5'-P1,P4-tetraphosphate + H2O | - |
Homo sapiens | ATP + AMP | - |
? | |
diadenosine 5',5'-P1,P4-tetraphosphate + H2O | - |
Lupinus angustifolius | ATP + AMP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
asymmetrical Ap4A hydrolase | - |
Homo sapiens |
asymmetrical Ap4A hydrolase | - |
Lupinus angustifolius |
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) | - |
Homo sapiens |
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) | - |
Lupinus angustifolius |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
30 | - |
assay at | Lupinus angustifolius |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Homo sapiens |
7.6 | - |
assay at | Lupinus angustifolius |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0015 | - |
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A | - |
Lupinus angustifolius | |
0.0021 | - |
A-5'-p-beta,beta'-methyleneoxy-p-5'-A | - |
Homo sapiens | |
0.0022 | - |
A-5'-p-beta,beta'-methyleneoxy-p-5'-A | - |
Lupinus angustifolius | |
0.0025 | - |
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A | - |
Homo sapiens |