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Literature summary for 3.6.1.17 extracted from

  • Guranowski, A.; Starzynska, E.; Pietrowska-Borek, M.; Rejman, D.; Blackburn, G.M.
    Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain: potential substrates and/or inhibitors of Ap4A hydrolases (2009), FEBS J., 276, 1546-1553.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A competitive inhibitor Homo sapiens
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A competitive inhibitor Lupinus angustifolius
A-5'-p-beta,beta'-methyleneoxy-p-5'-A competitive inhibitor Homo sapiens
A-5'-p-beta,beta'-methyleneoxy-p-5'-A competitive inhibitor Lupinus angustifolius

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.002
-
diadenosine 5',5'-P1,P4-tetraphosphate
-
Homo sapiens
0.0025
-
diadenosine 5',5'-P1,P4-tetraphosphate
-
Lupinus angustifolius

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 5 mM MgCl2 included in assay medium Homo sapiens
Mg2+ 5 mM MgCl2 included in assay medium Lupinus angustifolius

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
diadenosine 5',5'-P1,P4-tetraphosphate + H2O Homo sapiens
-
ATP + AMP
-
?
diadenosine 5',5'-P1,P4-tetraphosphate + H2O Lupinus angustifolius
-
ATP + AMP
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Lupinus angustifolius
-
-
-

Purification (Commentary)

Purification (Comment) Organism
symmetrical Ap4A hydrolase is partially purified from Escherichia coli Lupinus angustifolius

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A + H2O diadenosine polyphosphate analog Homo sapiens 2 alpha,beta-oxymethylene-ADP
-
?
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A + H2O diadenosine polyphosphate analog Lupinus angustifolius 2 alpha,beta-oxymethylene-ADP
-
?
betabeta'-methyleneoxy-Ap4A + H2O diadenosine polyphosphate analog Homo sapiens AMP + beta,gamma-methyleneoxy-ATP
-
?
betabeta'-methyleneoxy-Ap4A + H2O diadenosine polyphosphate analog Lupinus angustifolius AMP + beta,gamma-methyleneoxy-ATP
-
?
diadenosine 5',5'-P1,P4-tetraphosphate + H2O
-
Homo sapiens ATP + AMP
-
?
diadenosine 5',5'-P1,P4-tetraphosphate + H2O
-
Lupinus angustifolius ATP + AMP
-
?

Synonyms

Synonyms Comment Organism
asymmetrical Ap4A hydrolase
-
Homo sapiens
asymmetrical Ap4A hydrolase
-
Lupinus angustifolius
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
-
Homo sapiens
bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
-
Lupinus angustifolius

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Homo sapiens
30
-
assay at Lupinus angustifolius

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.6
-
assay at Homo sapiens
7.6
-
assay at Lupinus angustifolius

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0015
-
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A
-
Lupinus angustifolius
0.0021
-
A-5'-p-beta,beta'-methyleneoxy-p-5'-A
-
Homo sapiens
0.0022
-
A-5'-p-beta,beta'-methyleneoxy-p-5'-A
-
Lupinus angustifolius
0.0025
-
A-5'-p-alpha,beta,alpha',beta'-bis(oxymethylene)p-5'-A
-
Homo sapiens