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Literature summary for 3.6.1.17 extracted from
- Fluoride is a strong specific inhibitor of (asymmetrical) Ap4A hydrolases (1990), FEBS Lett., 262, 205-208.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| fluoride | non-competitive, strong inhibition, reversible | Bos taurus |  |
| fluoride | non-competitive, strong inhibition, reversible | Cucurbita pepo | |
| fluoride | non-competitive, strong inhibition, reversible | Helianthus sp. | |
| fluoride | non-competitive, strong inhibition, reversible | Lupinus sp. | |
| fluoride | non-competitive, strong inhibition, reversible | Saccharomyces cerevisiae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Lupinus sp. | - |
ATP + AMP | - |
? | |
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Saccharomyces cerevisiae | - |
ATP + AMP | - |
? | |
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Bos taurus | - |
ATP + AMP | - |
? | |
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Cucurbita pepo | - |
ATP + AMP | - |
? | |
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | Helianthus sp. | - |
ATP + AMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cucurbita pepo | - |
marrow | - |
| Helianthus sp. | - |
sunflower | - |
| Lupinus sp. | - |
yellow lupin | - |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Lupinus sp. |
- |
Saccharomyces cerevisiae |
- |
Bos taurus |
- |
Cucurbita pepo |
- |
Helianthus sp. |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
| seed | - |
Lupinus sp. | - |
| seed | - |
Cucurbita pepo | - |
| seed | - |
Helianthus sp. | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Lupinus sp. | ATP + AMP | - |
? | |
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Saccharomyces cerevisiae | ATP + AMP | - |
? | |
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Bos taurus | ATP + AMP | - |
? | |
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Cucurbita pepo | ATP + AMP | - |
? | |
| P1,P4-bis(5'-adenosyl) tetraphosphate + H2O | - |
Helianthus sp. | ATP + AMP | - |
? | |
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