Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | - |
Homo sapiens | |
(3-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | - |
Homo sapiens | |
(4-((4-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | - |
Homo sapiens | |
(4-((5,6-dichloro-2-cyclopropyl-4-nitro-1H-benzo[d]imidazol-1-yl)methyl)phenyl)boronic acid | - |
Homo sapiens | |
(4-((5,6-dichloro-2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-phenyl)boronic acid | - |
Homo sapiens | |
(4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | - |
Homo sapiens | |
(4-((5,6-difluoro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | - |
Homo sapiens | |
1-(4-(1H-pyrazol-1-yl)benzyl)-5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazole | - |
Homo sapiens | |
1-(4-(1H-pyrrol-1-yl)benzyl)-5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazole | - |
Homo sapiens | |
1-(4-methoxybenzyl)-1H-benzo[d]imidazole | - |
Homo sapiens | |
1-(4-methoxybenzyl)-2,5,6-trimethyl-1H-benzo[d]imidazole | - |
Homo sapiens | |
1-(4-methoxybenzyl)-2,5,6-trimethyl-4-nitro-1H-benzo[d]-imidazole | - |
Homo sapiens | |
1-(4-methoxybenzyl)-2-methyl-1H-benzo[d]imidazole | - |
Homo sapiens | |
1-(4-methoxybenzyl)-2-methyl-4-nitro-1H-benzo[d]imidazole | - |
Homo sapiens | |
1-(4-methoxybenzyl)-5,6-dimethyl-1H-benzo[d]imidazole | - |
Homo sapiens | |
1-(benzenesulfonyl)-5,6-dichloro-2-methyl-4-nitro-1H-benzimidazole | - |
Homo sapiens | |
1-benzyl-5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazole | - |
Homo sapiens | |
2-(4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl)methyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione | - |
Homo sapiens | |
4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl)methyl)phenol | - |
Homo sapiens | |
4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)-2-methylthiazole | - |
Homo sapiens | |
4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)benzaldehyde | - |
Homo sapiens | |
4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)benzoic acid | - |
Homo sapiens | |
4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)benzonitrile | - |
Homo sapiens | |
4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl acetate | - |
Homo sapiens | |
5,6-dichloro-1-((6-chloropyridin-3-yl)methyl)-2-methyl-4-nitro-1H-benzo[d]imidazole | - |
Homo sapiens | |
5,6-dichloro-1-(2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl)-2-methyl-4-nitro-1H-benzo[d]imidazole | - |
Homo sapiens | |
5,6-dichloro-1-(4-methoxybenzyl)-2-methyl-1H-benzo[d]-imidazole | - |
Homo sapiens | |
5,6-dichloro-1-(4-methoxybenzyl)-2-methyl-4-nitro-1H-benzo-[d]imidazole | - |
Homo sapiens | |
5,6-dichloro-2-methyl-1-(4-methylbenzyl)-4-nitro-1H-benzo[d]-imidazole | - |
Homo sapiens | |
5,6-dichloro-2-methyl-4-nitro-1-(phenylsulfonyl)-1H-benzo[d]imidazole | - |
Homo sapiens | |
5,6-dichloro-2-methyl-4-nitro-1-phenyl-1H-benzo-[d]imidazole | - |
Homo sapiens | |
5-aza-dCTP | - |
Homo sapiens | |
boronate | - |
Homo sapiens | |
decitabine | - |
Homo sapiens | |
methyl 4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)methyl)benzoate | - |
Homo sapiens | |
additional information | discovery of selective inhibitors of human dCTP pyrophosphatase 1, synthesis of a series of benzimidazole derivatives, overview. N-Methyliminodiacetic acid (MIDA) boronate esters can be prepared from the parent boronic acids using Knapp's procedure. No inhibition by 1-(4-methoxybenzyl)-2-methyl-1H-benzo[d]imidazole | Homo sapiens | |
triptolide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9H773 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HL-60 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
all-alpha nucleoside triphosphate pyrophosphatase | - |
Homo sapiens |
dCTP pyrophosphatase 1 | - |
Homo sapiens |
dCTPase | - |
Homo sapiens |
NTP pyrophosphatase | - |
Homo sapiens |
XTP3TPA | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000019 | - |
pH 8.0, 22°C | Homo sapiens | 5,6-dichloro-2-methyl-1-(4-methylbenzyl)-4-nitro-1H-benzo[d]-imidazole | |
0.000021 | - |
pH 8.0, 22°C | Homo sapiens | 4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl)methyl)phenol | |
0.000027 | - |
pH 8.0, 22°C | Homo sapiens | (4-((5,6-dichloro-2-cyclopropyl-4-nitro-1H-benzo[d]imidazol-1-yl)methyl)phenyl)boronic acid | |
0.000034 | - |
pH 8.0, 22°C | Homo sapiens | 4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl acetate | |
0.000041 | - |
pH 8.0, 22°C | Homo sapiens | 5,6-dichloro-1-(4-methoxybenzyl)-2-methyl-4-nitro-1H-benzo-[d]imidazole | |
0.000046 | - |
pH 8.0, 22°C | Homo sapiens | (2-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | |
0.000046 | - |
pH 8.0, 22°C | Homo sapiens | (4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | |
0.000047 | - |
pH 8.0, 22°C | Homo sapiens | 2-(4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]-imidazol-1-yl)methyl)phenyl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione | |
0.000049 | - |
pH 8.0, 22°C | Homo sapiens | 1-benzyl-5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazole | |
0.000057 | - |
pH 8.0, 22°C | Homo sapiens | 1-(4-methoxybenzyl)-2,5,6-trimethyl-4-nitro-1H-benzo[d]-imidazole | |
0.000073 | - |
pH 8.0, 22°C | Homo sapiens | 4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)benzoic acid | |
0.000074 | - |
pH 8.0, 22°C | Homo sapiens | 1-(benzenesulfonyl)-5,6-dichloro-2-methyl-4-nitro-1H-benzimidazole | |
0.000075 | - |
pH 8.0, 22°C | Homo sapiens | 1-(4-(1H-pyrazol-1-yl)benzyl)-5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazole | |
0.000082 | - |
pH 8.0, 22°C | Homo sapiens | (3-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | |
0.000085 | - |
pH 8.0, 22°C | Homo sapiens | 5,6-dichloro-2-methyl-4-nitro-1-phenyl-1H-benzo-[d]imidazole | |
0.000095 | - |
pH 8.0, 22°C | Homo sapiens | methyl 4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)methyl)benzoate | |
0.000109 | - |
pH 8.0, 22°C | Homo sapiens | 5,6-dichloro-1-(2-(3,5-dimethyl-1H-pyrazol-4-yl)ethyl)-2-methyl-4-nitro-1H-benzo[d]imidazole | |
0.000133 | - |
pH 8.0, 22°C | Homo sapiens | 4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)benzaldehyde | |
0.000165 | - |
pH 8.0, 22°C | Homo sapiens | 4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)benzonitrile | |
0.000185 | - |
pH 8.0, 22°C | Homo sapiens | 5,6-dichloro-1-((6-chloropyridin-3-yl)methyl)-2-methyl-4-nitro-1H-benzo[d]imidazole | |
0.000205 | - |
pH 8.0, 22°C | Homo sapiens | 5,6-dichloro-2-methyl-4-nitro-1-(phenylsulfonyl)-1H-benzo[d]imidazole | |
0.000206 | - |
pH 8.0, 22°C | Homo sapiens | (4-((4-nitro-2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | |
0.00024 | - |
pH 8.0, 22°C | Homo sapiens | 4-((5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)-2-methylthiazole | |
0.000248 | - |
pH 8.0, 22°C | Homo sapiens | (4-((5,6-dichloro-2-methyl-1H-benzo[d]imidazol-1-yl)methyl)-phenyl)boronic acid | |
0.000331 | - |
pH 8.0, 22°C | Homo sapiens | 1-(4-(1H-pyrrol-1-yl)benzyl)-5,6-dichloro-2-methyl-4-nitro-1H-benzo[d]imidazole | |
0.000529 | - |
pH 8.0, 22°C | Homo sapiens | (4-((5,6-difluoro-2-methyl-4-nitro-1H-benzo[d]imidazol-1-yl)-methyl)phenyl)boronic acid | |
0.00145 | - |
pH 8.0, 22°C | Homo sapiens | 1-(4-methoxybenzyl)-2-methyl-4-nitro-1H-benzo[d]imidazole | |
0.012 | - |
pH 8.0, 22°C | Homo sapiens | 5,6-dichloro-1-(4-methoxybenzyl)-2-methyl-1H-benzo[d]-imidazole | |
0.022 | - |
pH 8.0, 22°C | Homo sapiens | 1-(4-methoxybenzyl)-2,5,6-trimethyl-1H-benzo[d]imidazole | |
0.1 | - |
pH 8.0, 22°C | Homo sapiens | 1-(4-methoxybenzyl)-1H-benzo[d]imidazole | |
0.1 | - |
pH 8.0, 22°C | Homo sapiens | 1-(4-methoxybenzyl)-2-methyl-1H-benzo[d]imidazole | |
0.1 | - |
pH 8.0, 22°C | Homo sapiens | 1-(4-methoxybenzyl)-5,6-dimethyl-1H-benzo[d]imidazole |
General Information | Comment | Organism |
---|---|---|
malfunction | potent and selective dCTPase inhibitors enhance the cytotoxic effect of cytidine analogues in leukemia cells | Homo sapiens |
physiological function | the dCTPase pyrophosphatase 1 (dCTPase) is an all-alpha nucleoside triphosphate (NTP) pyrophosphatase responsible for dNTP pool house-cleaning. It regulates the intracellular nucleotide pool through hydrolytic degradation of canonical and noncanonical nucleotide triphosphates (dNTPs). dCTPase is highly expressed in multiple carcinomas and is associated with cancer cell stemness | Homo sapiens |