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Literature summary for 3.6.1.11 extracted from

  • Guranowski, A.; Starzynska, E.; Barnes, L.D.; Robinson, A.K.; Liu, S.
    Adenosine 5'-tetraphosphate phosphohydrolase activity is an inherent property of soluble exopolyphosphatase from yeast Saccharomyces cerevisiae (1998), Biochim. Biophys. Acta, 1380, 232-238.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ammonium molybdate
-
Saccharomyces cerevisiae
o-vanadate
-
Saccharomyces cerevisiae
ZnCl2
-
Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.08
-
adenosine 5'-tetraphosphate at pH 4.8, 50 mM sodium acetate, 5 mM CoCl2 Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ divalent cation required, order of decreasing stimulation: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
Mg2+ divalent cation required, order of decreasing stimulation: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
Mn2+ divalent cation required, order of decreasing stimulation: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae
Ni2+ divalent cation required, order of decreasing stimulation: Co2+, Mn2+, Mg2+, Ni2+ Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(polyphosphate)n + H2O
-
Saccharomyces cerevisiae (polyphosphate)n-1 + phosphate
-
?
adenosine 5'-pentaphosphate + H2O
-
Saccharomyces cerevisiae ?
-
?
adenosine 5'-tetraphosphate + H2O
-
Saccharomyces cerevisiae ATP + phosphate
-
?
guanosine-5'-tetraphosphate + H2O
-
Saccharomyces cerevisiae GTP + phosphate
-
?
inosine tetraphosphate + H2O
-
Saccharomyces cerevisiae ITP + phosphate
-
?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
40
-
adenosine-5'-pentaphosphate
-
Saccharomyces cerevisiae
723
-
adenosine 5'-tetraphosphate
-
Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
4.8
-
in presence of Co2+ Saccharomyces cerevisiae

pH Range

pH Minimum pH Maximum Comment Organism
3.8 7.2 50% of maximal activity at pH 3.8 and at pH 7.2 Saccharomyces cerevisiae