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Literature summary for 3.6.1.1 extracted from
- Age-dependent differential expression and activity of rat liver cytosolic inorganic pyrophosphatase gene (2007), Biogerontology, 8, 517-525.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| quantitative tissue-specific expression analysis | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CaCl2 | - |
Rattus norvegicus |  |
| NaCl | - |
Rattus norvegicus | |
| NaF | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diphosphate + H2O | Rattus norvegicus | intracellular diphosphate is a by-product of multiple biosynthetic reactions and its hydrolysis by cytosolic iPPase is an important homeostatic mechanism favoring biosynthesis, overview | 2 phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male Fisher 344 rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | high activity in liver, age-dependent differential expression and activity, liver of 24 months-old rats has a 2fold more activity than the adult 4-months-old one, overview | Rattus norvegicus | - |
| muscle | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
tissue-specific activities in absence and presence of salts, overview | Rattus norvegicus |
| 0.5 | - |
liver enzyme in absence of NaCl | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| diphosphate + H2O | - |
Rattus norvegicus | 2 phosphate | - |
? | |
| diphosphate + H2O | intracellular diphosphate is a by-product of multiple biosynthetic reactions and its hydrolysis by cytosolic iPPase is an important homeostatic mechanism favoring biosynthesis, overview | Rattus norvegicus | 2 phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| inorganic pyrophosphatase | - |
Rattus norvegicus |
| IPPase | - |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.6 | - |
narrow pH spectrum of iPPase | Rattus norvegicus |
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Release 2023.1 (January 2023)
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