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Literature summary for 3.5.4.6 extracted from

  • Rybakowska, I.; Swieca, A.; Milczarek, R.; Klimek, J.; Kaletha, K.
    AMP-deaminase from human preterm placenta - kinetic regulatory properties of enzyme (2011), Placenta, 32, 704-707.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
phosphate competitive inhibitor of the term placenta enzyme, AMP-deaminase from preterm placenta is not inhibited by physiological concentrations of orthophosphate at low substrate concentration range in contrast to the enzyme from the term organ Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information at pH 7.0 the reaction catalysed by AMP-deaminase from human preterm placenta follows a well depicted sigmoid-shaped kinetic profile, with a half-saturation constant (S0.5) value of about 9.2 mM. Phosphate hardly influences the kinetic profile diminishing the S0.5 constant value slightly to 8.1 mM. Addition into the medium of 1 mM adenine nucleotide, ADP or ATP, transforms the sigmoid-shaped profile of the control kinetic curve into a hyperbolic one, diminishing simultaneously the value of the S0.5 constant from 9.2 mM to 2.4 mM, respectively. Kinetic analysis, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
AMP + H2O Homo sapiens
-
IMP + NH3
-
ir

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from human term and preterm placenta Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
placenta preterm placenta. During pregnancy the isoform composition of human placental AMP-deaminase changes. High catalytic efficiency of the enzyme at early phase of the pregnancy Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
AMP + H2O
-
Homo sapiens IMP + NH3
-
ir

Synonyms

Synonyms Comment Organism
AMP-deaminase
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
AMP-deaminase from preterm placenta is less sensitive to pH changes compared to the enzyme from the term organ Homo sapiens

General Information

General Information Comment Organism
physiological function during pregnancy the isoform composition of human placental AMP-deaminase changes as an adaptation of enzyme to changing metabolic requirements of the growing fetus, overview Homo sapiens