Inhibitors | Comment | Organism | Structure |
---|---|---|---|
phosphate | competitive inhibitor of the term placenta enzyme, AMP-deaminase from preterm placenta is not inhibited by physiological concentrations of orthophosphate at low substrate concentration range in contrast to the enzyme from the term organ | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | at pH 7.0 the reaction catalysed by AMP-deaminase from human preterm placenta follows a well depicted sigmoid-shaped kinetic profile, with a half-saturation constant (S0.5) value of about 9.2 mM. Phosphate hardly influences the kinetic profile diminishing the S0.5 constant value slightly to 8.1 mM. Addition into the medium of 1 mM adenine nucleotide, ADP or ATP, transforms the sigmoid-shaped profile of the control kinetic curve into a hyperbolic one, diminishing simultaneously the value of the S0.5 constant from 9.2 mM to 2.4 mM, respectively. Kinetic analysis, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
AMP + H2O | Homo sapiens | - |
IMP + NH3 | - |
ir |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme from human term and preterm placenta | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
placenta | preterm placenta. During pregnancy the isoform composition of human placental AMP-deaminase changes. High catalytic efficiency of the enzyme at early phase of the pregnancy | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
AMP + H2O | - |
Homo sapiens | IMP + NH3 | - |
ir |
Synonyms | Comment | Organism |
---|---|---|
AMP-deaminase | - |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
AMP-deaminase from preterm placenta is less sensitive to pH changes compared to the enzyme from the term organ | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | during pregnancy the isoform composition of human placental AMP-deaminase changes as an adaptation of enzyme to changing metabolic requirements of the growing fetus, overview | Homo sapiens |