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Literature summary for 3.5.4.6 extracted from
- AMP deaminase and adenosine deaminase activities in liver and brain regions in acute ammonia intoxication and subacute toxic hepatitis (2010), Brain Res., 1311, 175-181.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| cerebellum | - |
Rattus norvegicus | - |
| hippocampus | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| neocortex | - |
Rattus norvegicus | - |
| striatum | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AMP + H2O | - |
Rattus norvegicus | IMP + NH3 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| adenylate deaminase | - |
Rattus norvegicus |
| AmpD | - |
Rattus norvegicus |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | AMP deaminase in the liver is elevated by 4.2fold in models of hepatotoxic injury as compared with controls. In acute hyperammonemia, activity of AMP deaminase increases by 59% in the neocortex. In the hippocampus of hyperammonemic rats, AMP deaminase activity is increased by 48%. Subacute hepatitis leads to 228% increase in AMP deaminase activity | up |
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