Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | at pH 5.9 in the absence of fluoride, ATP exerts a biphasic effect; less than 0.003 mM ATP act as an inhibitor, whereas increasing ATP concentrations above 0.003 mM reverse the inhibition | Oryctolagus cuniculus | |
fluoride | over the pH range 5.9-7.5 fluoride ion acts as pure uncompetitive inhibitor of AMPD, with the Ki increasing from 1 to 30 mM | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dinuclear cocatalytic Zn site, the two Zn2+ ions in the AMPD metallocenter operate together as a single catalytic unit, but have independent functions | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
skeletal muscle | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
AMP + H2O | - |
Oryctolagus cuniculus | IMP + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | presence of two species of 173 kDa and 309 kDa being consistent with the existence of a dimer-tetramer equilibrium | Oryctolagus cuniculus |
Synonyms | Comment | Organism |
---|---|---|
AmpD | - |
Oryctolagus cuniculus |