Literature summary for 3.5.4.5 extracted from

Kuraoka, M.; Holl, T.M.; Liao, D.; Womble, M.; Cain, D.W.; Reynolds, A.E.; Kelsoe, G.
Activation-induced cytidine deaminase mediates central tolerance in B cells (2011), Proc. Natl. Acad. Sci. USA, 108, 11560-11565.

Search for more literature for 3.5.4.5

Organism

Organism	UniProt	Comment	Textmining

General Information

General Information	Comment	Organism
malfunction	impaired central B-cell tolerance and increased serum autoAb in Aicda-/- mice compared to the wild-type	Mus musculus
physiological function	activation-induced cytidine deaminase initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig genes by the deamination of deoxycytidine, followed by error-prone mismatch- or base-excision DNA repair. Aicda impairs B-cell development	Mus musculus

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Release 2023.1 (January 2023)