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Literature summary for 3.5.4.5 extracted from

  • Kara, J.; Bartova, M.; Ryba, M.; Hrebabecky, H.; Brokes, J.; Novotny, L.; Baranek, J.
    Sensitivity of some arabinosylcytosine derivatives to enzymatic deamination by cytidine deaminase from mouse kidney (1982), Collect. Czech. Chem. Commun., 47, 2824-2830.
No PubMed abstract available
Search for more literature for 3.5.4.5

Inhibitors

Inhibitors Comment Organism Structure
2-beta-D-ribofuranosyl-1,2,4-triazol-3-one
-
 Mus musculus
6-thioguanine
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytidine + H2O Mus musculus
-
 uridine + NH3
-
 ?
cytidine + H2O Mus musculus BALB/c
-
 uridine + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 mouse
-
Mus musculus
-
 BALB/c
-
Mus musculus BALB/c
-
 BALB/c
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Mus musculus
-

Storage Stability

Storage Stability Organism
-20°C, 0.005 M dithiothreitol, enzymatic activity is stable for many weeks Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-beta-D-arabinofuranosylcytosine + H2O araC, most effective agent in therapy of acute myeloblastic leukemia Mus musculus ?
-
 ?
2',5'-anhydroarabinosylcytosine + H2O
-
 Mus musculus 2',5'-anhydroarabinosyluracil + NH3
-
 ?
2',5'-anhydroarabinosylcytosine + H2O
-
 Mus musculus BALB/c 2',5'-anhydroarabinosyluracil + NH3
-
 ?
5'-bromoarabinosylcytosine + H2O
-
 Mus musculus 5'-bromoarabinosyluracil + NH3
-
 ?
5'-chloroarabinosylcytosine + H2O
-
 Mus musculus 5'-chloroarabinosyluracil + NH3
-
 ?
cytidine + H2O
-
 Mus musculus uridine + NH3
-
 ?
cytidine + H2O
-
 Mus musculus BALB/c uridine + NH3
-
 ?
cytosine arabinoside + H2O
-
 Mus musculus uridine arabinoside + NH3
-
 ?
cytosine arabinoside + H2O
-
 Mus musculus BALB/c uridine arabinoside + NH3
-
 ?
additional information cyclocytidine, N-4-acetylarabinosylcytosine, tetraacetylarabinosylcytosine, N4-behenoylarabinosylcytosine and tri-O-acetylarabinosylcytosine are no substrates Mus musculus ?
-
 ?
additional information cyclocytidine, N-4-acetylarabinosylcytosine, tetraacetylarabinosylcytosine, N4-behenoylarabinosylcytosine and tri-O-acetylarabinosylcytosine are no substrates Mus musculus BALB/c ?
-
 ?
N-4-monoacetylarabinosylcytosine
-
 Mus musculus uracil arabinoside + carbamate
-
 ?
N-4-monoacetylarabinosylcytosine
-
 Mus musculus BALB/c uracil arabinoside + carbamate
-
 ?