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Literature summary for 3.5.4.5 extracted from

  • Cohen, R.M.; Wolfenden, R.
    Cytidine deaminase from Escherichia coli. Purification, properties and inhibition by the potential transition state analog 3,4,5,6-tetrahydrouridine (1971), J. Biol. Chem., 246, 7561-7565.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3,4,5,6-Tetrahydrouridine potent competitive inhibitor Escherichia coli
3,4,5,6-Tetrahydrouridine potent competitive inhibitor Homo sapiens
3,4,5,6-Tetrahydrouridine potent competitive inhibitor Mus musculus
5,6-Dihydrouridine competitive inhibition Escherichia coli
5,6-Dihydrouridine
-
Homo sapiens
uridine product inhibition Escherichia coli
uridine
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
cytidine at pH 7.5 with H2O and pH 8.4 with H2O or D2O Escherichia coli
0.208
-
cytidine at pH 7.5 with D2O Escherichia coli
0.233
-
cytidine at pH 7.1 with D2O Escherichia coli
0.238
-
cytidine at pH 7.1 with D2O Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
73000
-
gel filtration, nonhomogenous preparation Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytidine + H2O Mus musculus
-
uridine + NH3
-
?
cytidine + H2O Escherichia coli
-
uridine + NH3
-
?
cytidine + H2O Homo sapiens
-
uridine + NH3
-
?
cytidine + H2O Saccharomyces cerevisiae
-
uridine + NH3
-
?
cytidine + H2O Ovis aries
-
uridine + NH3
-
?
cytidine + H2O Escherichia coli B / ATCC 11303
-
uridine + NH3
-
?
cytidine + H2O Mus musculus BALB/c
-
uridine + NH3
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli B / ATCC 11303
-
-
-
Homo sapiens
-
human
-
Mus musculus
-
mouse
-
Mus musculus
-
BALB/c
-
Mus musculus BALB/c
-
BALB/c
-
Ovis aries
-
-
-
Saccharomyces cerevisiae
-
bakers' yeast
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Mus musculus
-
kidney
-
Homo sapiens
-
liver
-
Mus musculus
-
liver
-
Homo sapiens
-
liver
-
Ovis aries
-

Storage Stability

Storage Stability Organism
4°C, reasonably stable, retains 55% of its activity after 3 weeks Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytidine + H2O
-
Mus musculus uridine + NH3
-
?
cytidine + H2O
-
Escherichia coli uridine + NH3
-
?
cytidine + H2O
-
Homo sapiens uridine + NH3
-
?
cytidine + H2O
-
Saccharomyces cerevisiae uridine + NH3
-
?
cytidine + H2O
-
Ovis aries uridine + NH3
-
?
cytidine + H2O
-
Escherichia coli B / ATCC 11303 uridine + NH3
-
?
cytidine + H2O
-
Mus musculus BALB/c uridine + NH3
-
?
N4-methylcytidine + H2O
-
Escherichia coli uridine + methylamine
-
r
N4-methylcytidine + H2O
-
Escherichia coli B / ATCC 11303 uridine + methylamine
-
r

pH Range

pH Minimum pH Maximum Comment Organism
6 11
-
Escherichia coli