BRENDA - Enzyme Database
show all sequences of 3.5.4.5

Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer

Sigmond, J.; Honeywell, R.J.; Postma, T.J.; Dirven, C.M.; de Lange, S.M.; van der Born, K.; Laan, A.C.; Baayen, J.C.; Van Groeningen, C.J.; Bergman, A.M.; Giaccone, G.; Peters, G.J.; Ann. Oncol. 20, 182-187 (2009)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
studies on radiosensitization of glioblastoma multiforme (GBM), deoxynucleoside analogue gemcitabine (dFdC) considered for combination therapy with radiation in glioblastomas
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0092
-
2',2'-difluorodeoxycytidine
i.e. gemcitabine, variation of plasma gemcitabine between 0.9 and 9.2 microM
Homo sapiens
0.0726
-
2',2'-difluorodeoxyuridine
i.e. dFdU, variation of plasma ranges between 24.9 and 72.6 microM
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
deoxycytidine + H2O
Homo sapiens
-
deoxyuridine + NH3
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Homo sapiens
-
glioblastoma multiforme (GBM) patients
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
blood plasma
glioblastoma multiforme (GBM) patients
Homo sapiens
-
glioblastoma multiforme cell
glioblastoma multiforme (GBM) patients
Homo sapiens
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
variation between 1.51 to 5.50 nmol/h/mg protein, about 100-fold lower than that in liver
Homo sapiens
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2',2'-difluorodeoxycytidine + H2O
deamination of the deoxynucleoside analogue gemcitabine (dFdC) to difluorodeoxyuridine (dFdU), difluorodeoxyuridine used as radiosensitizer in gene therapy
695606
Homo sapiens
2',2'-difluorodeoxyuridine + NH3
-
-
-
?
deoxycytidine + H2O
-
695606
Homo sapiens
deoxyuridine + NH3
-
-
-
?
Synonyms
Synonyms
Commentary
Organism
dCDA
-
Homo sapiens
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
medicine
studies on radiosensitization of glioblastoma multiforme (GBM), deoxynucleoside analogue gemcitabine (dFdC) considered for combination therapy with radiation in glioblastomas
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.0092
-
2',2'-difluorodeoxycytidine
i.e. gemcitabine, variation of plasma gemcitabine between 0.9 and 9.2 microM
Homo sapiens
0.0726
-
2',2'-difluorodeoxyuridine
i.e. dFdU, variation of plasma ranges between 24.9 and 72.6 microM
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
deoxycytidine + H2O
Homo sapiens
-
deoxyuridine + NH3
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
blood plasma
glioblastoma multiforme (GBM) patients
Homo sapiens
-
glioblastoma multiforme cell
glioblastoma multiforme (GBM) patients
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
additional information
-
variation between 1.51 to 5.50 nmol/h/mg protein, about 100-fold lower than that in liver
Homo sapiens
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2',2'-difluorodeoxycytidine + H2O
deamination of the deoxynucleoside analogue gemcitabine (dFdC) to difluorodeoxyuridine (dFdU), difluorodeoxyuridine used as radiosensitizer in gene therapy
695606
Homo sapiens
2',2'-difluorodeoxyuridine + NH3
-
-
-
?
deoxycytidine + H2O
-
695606
Homo sapiens
deoxyuridine + NH3
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Homo sapiens
Other publictions for EC 3.5.4.5
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
752690
Liu
Biochemical and structural an ...
Klebsiella pneumoniae subsp. pneumoniae, Klebsiella pneumoniae subsp. pneumoniae ATCC 700721
Biochem. Biophys. Res. Commun.
519
280-286
2019
-
-
-
1
-
-
-
-
-
1
1
-
-
5
-
-
-
-
-
-
-
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4
1
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1
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1
1
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-
-
4
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
753820
Furusho
Cytidine deaminase enables To ...
Homo sapiens
Int. Immunol.
31
167-173
2019
-
-
-
-
-
-
-
-
-
-
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1
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2
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1
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2
-
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-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
753114
Tibaldi
Cytidine deaminase enzymatic ...
Homo sapiens
Br. J. Cancer
119
1326-1331
2018
-
1
-
-
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-
-
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-
-
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2
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2
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1
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1
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2
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-
755377
Sanchez-Quitian
-
Functional and structural evi ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
RSC Adv.
5
830-840
2015
-
-
-
1
5
-
-
3
-
1
1
-
-
4
-
-
1
-
-
-
2
-
4
1
-
-
-
-
3
-
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-
1
5
-
-
-
-
3
-
1
1
-
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-
1
-
-
2
-
4
1
-
-
-
3
-
-
-
-
-
-
-
-
3
3
734018
Shibu
Characterization of a novel re ...
Brassica oleracea
J. Agric. Food Chem.
62
1796-1801
2014
-
-
1
-
-
-
-
2
-
-
1
3
-
15
-
-
1
-
-
-
-
-
3
1
2
1
-
-
-
1
-
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-
-
-
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-
1
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-
-
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-
-
2
-
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1
3
-
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-
1
-
-
-
-
3
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
718695
Sanchez-Quitian
Crystal structure determinatio ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
Arch. Biochem. Biophys.
509
108-115
2011
-
1
-
1
-
-
-
-
-
-
-
-
-
7
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
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1
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1
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1
-
-
-
-
-
-
-
-
-
2
2
-
-
-
712889
Sanchez-Quitian
Structural and functional anal ...
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
J. Struct. Biol.
169
413-423
2010
-
-
1
1
-
-
-
2
-
1
4
-
-
9
-
-
1
-
-
-
4
-
4
3
1
-
-
-
2
-
-
-
-
-
-
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-
-
1
-
1
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2
-
1
4
-
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-
1
-
-
4
-
4
3
-
-
-
2
-
-
-
-
-
1
1
-
-
-
685915
Lemaire
Inhibition of cytidine deamina ...
Homo sapiens
Cancer Chemother. Pharmacol.
63
411-416
2009
-
-
1
-
-
-
1
1
-
-
-
2
-
8
-
-
1
-
-
-
-
-
4
-
1
1
-
-
-
1
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1
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1
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1
1
1
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2
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1
-
-
-
-
4
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
695606
Sigmond
Gemcitabine uptake in glioblas ...
Homo sapiens
Ann. Oncol.
20
182-187
2009
-
1
-
-
-
-
-
2
-
-
-
1
-
3
-
-
-
-
-
2
1
-
2
-
1
1
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-
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1
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2
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1
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2
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
711824
Wu
Identification and functional ...
Haliotis diversicolor supertexta
Dev. Comp. Immunol.
33
709-717
2009
-
-
1
-
-
-
-
-
2
1
2
1
-
7
-
-
1
-
-
5
-
-
1
2
2
-
-
-
-
-
-
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-
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1
-
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1
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2
1
2
1
-
-
-
1
-
5
-
-
1
2
-
-
-
-
-
-
-
1
1
1
1
1
-
-
712721
Park
Thermostability of chimeric cy ...
Geobacillus stearothermophilus, [Bacillus] caldolyticus, Geobacillus stearothermophilus IFO12550 (T101), [Bacillus] caldolyticus DSM 405 (T53)
J. Microbiol. Biotechnol.
19
1536-1541
2009
-
-
2
-
-
-
-
-
-
-
4
-
-
6
-
-
2
-
-
-
-
-
4
2
4
-
-
2
-
-
-
-
-
-
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-
-
2
-
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-
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-
-
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-
4
-
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-
2
-
-
-
-
4
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
699156
Besnard
Optimized blood sampling with ...
Homo sapiens
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
870
117-120
2008
-
-
-
-
-
-
1
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1
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3
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2
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2
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2
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1
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1
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2
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-
2
-
-
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-
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-
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-
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-
-
-
-
700510
Giovannetti
Correlation between cytidine d ...
Homo sapiens
Nucleosides Nucleotides Nucleic Acids
27
720-725
2008
-
1
-
-
-
-
-
-
-
-
-
1
-
3
-
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-
1
2
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2
-
2
1
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1
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1
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1
2
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2
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1
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-
-
-
686066
Matsubara
-
The ONIOM molecular dynamics m ...
Homo sapiens
Chem. Phys. Lett.
437
138-142
2007
-
-
-
-
-
-
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1
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2
-
1
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3
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3
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689935
Vincenzetti
Modulation of human cytidine d ...
Homo sapiens
Proteins
70
144-156
2007
-
-
1
-
7
-
4
13
-
-
-
-
-
12
-
-
1
-
-
-
-
-
4
1
1
2
2
1
-
1
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11
-
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1
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7
-
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4
11
13
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1
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4
1
2
2
1
-
1
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-
-
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-
-
-
-
689995
Parise
Quantitative determination of ...
Mus musculus
Rapid Commun. Mass Spectrom.
21
1991-1997
2007
-
-
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1
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1
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4
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2
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1
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1
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667736
Teh
The 1.48 A resolution crystal ...
Mus musculus
Biochemistry
45
7825-7833
2006
-
-
1
2
-
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2
-
-
2
-
2
-
6
-
-
1
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4
1
1
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1
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2
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2
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2
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2
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1
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4
1
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669610
Matsubara
A quantum chemical study of th ...
Escherichia coli
J. Chem. Inf. Model.
46
1276-1285
2006
-
-
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1
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1
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-
669910
Costanzi
Human cytidine deaminase: A th ...
Homo sapiens
J. Mol. Graph. Model.
25
10-16
2006
-
-
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1
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9
-
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1
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-
-
-
669137
Elshafei
Cytidine deaminase activity in ...
Penicillium palitans, Penicillium palitans NRC 510
J. Basic Microbiol.
45
335-343
2005
-
-
-
-
-
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3
-
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3
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8
-
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1
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2
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1
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3
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3
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1
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2
-
1
-
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-
669792
Chung
Structure of human cytidine de ...
Homo sapiens
J. Med. Chem.
48
658-660
2005
-
-
-
1
-
-
1
-
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6
-
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-
-
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1
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1
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1
1
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654757
Johansson
Structural, kinetic, and mutat ...
Bacillus subtilis
Biochemistry
43
6020-6029
2004
-
-
1
1
5
-
-
6
-
1
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1
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1
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2
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670747
Vincenzetti
Isoenzymatic forms of human cy ...
Homo sapiens
Protein Eng. Des. Sel.
17
871-877
2004
-
-
-
-
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-
6
11
-
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2
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6
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2
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5
1
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12
3
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6
12
11
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2
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2
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5
1
-
-
-
-
-
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-
3
-
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-
657227
Vincenzetti
Functional properties of subun ...
Homo sapiens
Protein Eng.
16
1055-1061
2003
-
-
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1
-
2
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8
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1
1
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1
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-
-
-
-
-
-
-
-
650635
Sakai
Isolation from Nocardioides sp ...
Nocardioides sp., Nocardioides sp. CT16
Biosci. Biotechnol. Biochem.
66
1646-1651
2002
-
-
-
-
-
-
-
3
-
-
2
-
-
7
-
-
1
-
-
-
1
-
10
1
-
1
-
5
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
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3
-
-
2
-
-
-
-
1
-
-
1
-
10
1
1
-
5
-
-
-
-
-
-
-
-
-
-
-
654638
Johansson
Crystal structure of the tetra ...
Bacillus subtilis
Biochemistry
41
2563-2570
2002
-
-
-
1
-
-
-
-
-
1
-
-
-
6
-
-
-
-
-
-
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-
1
1
-
-
-
-
-
-
-
-
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-
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1
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-
-
-
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1
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-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657220
Cambi
Cytidine deaminase from two ex ...
Bacillus subtilis, [Bacillus] caldolyticus, Sporosarcina psychrophila
Protein Eng.
14
807-813
2001
-
-
2
-
-
2
-
-
-
-
4
-
-
12
-
-
2
-
1
-
-
-
3
4
3
3
3
3
-
-
-
-
-
-
3
-
-
-
2
-
-
-
2
-
-
-
-
-
-
4
-
-
-
-
2
1
-
-
-
3
4
3
3
3
-
-
-
-
3
-
-
-
-
-
-
209667
Carlow
Cytidine deaminases from B. su ...
Bacillus subtilis, Escherichia coli, Homo sapiens, Escherichia coli SO268
Biochemistry
38
12258-12265
1999
-
-
1
-
-
-
11
-
-
-
2
4
-
10
-
-
-
-
-
-
2
-
4
2
-
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-
-
-
-
2
-
-
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-
-
1
-
-
-
-
-
11
-
-
-
-
2
4
-
-
-
-
-
-
2
-
4
2
-
-
-
-
-
2
-
-
-
-
-
-
-
-
209668
Vincenzetti
Cloning, expression, and purif ...
Arabidopsis thaliana, Bacillus subtilis, Gallus gallus, Escherichia coli, Haemophilus influenzae, Ovis aries, Mus musculus, Escherichia coli SO5201, Mus musculus BALB/c
Protein Expr. Purif.
15
8-15
1999
-
-
1
1
-
-
15
10
-
-
6
9
-
78
-
-
1
-
-
-
1
-
26
4
-
-
-
-
-
-
1
1
-
-
-
-
-
-
1
-
1
-
-
-
15
-
10
-
-
6
9
-
-
-
1
-
-
1
-
26
4
-
-
-
-
-
1
1
-
-
-
-
-
-
-
209669
Faivre-Nitschke
A prokaryotic-type cytidine de ...
Arabidopsis thaliana, Bacillus subtilis, Saccharomyces cerevisiae, Brugia pahangi, Caenorhabditis elegans, Escherichia coli, Haemophilus influenzae, Homo sapiens, Mycoplasma pneumoniae, Escherichia coli BL21(D3)
Eur. J. Biochem.
263
896-903
1999
-
1
1
-
-
-
11
6
2
-
2
10
-
24
-
-
-
-
-
-
-
1
24
3
-
-
-
-
-
1
1
-
-
-
-
-
-
1
1
-
-
-
-
-
11
-
6
2
-
2
10
-
-
-
-
-
-
-
1
24
3
-
-
-
-
1
1
-
-
-
-
-
-
-
-
209534
Kroep
Role of deoxycytidine kinase ( ...
Homo sapiens
Adv. Exp. Med. Biol.
431
657-660
1998
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
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-
1
-
-
-
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-
1
-
-
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-
-
1
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209531
Jahns-Streubel
-
Correlation of deoxycytidine d ...
Homo sapiens
Haematol. Blood Transfus.
38
252-259
1997
-
-
1
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209666
Vincenzetti
Human placenta cytidine deamin ...
Bacillus subtilis, Homo sapiens
Biochemistry
42
469-476
1997
-
-
1
-
-
-
2
-
-
-
-
2
-
7
-
-
1
-
-
10
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
-
-
-
-
2
-
-
-
1
-
10
-
-
3
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209665
Vincenzetti
Recombinant human cytidine dea ...
Bacillus subtilis, Escherichia coli, Homo sapiens, Escherichia coli DH5-alpha
Protein Expr. Purif.
8
247-253
1996
-
-
1
1
-
-
9
6
-
-
6
4
-
25
-
-
1
-
-
8
1
1
13
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
9
-
6
-
-
6
4
-
-
-
1
-
8
1
1
13
4
-
-
-
-
-
1
-
-
-
-
-
-
-
-
209642
Betts
Cytidine deaminase.The 2.3 A c ...
Escherichia coli
J. Mol. Biol.
235
635-656
1994
-
-
-
1
-
-
-
-
-
-
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1
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209664
Smith
Mutations affecting transition ...
Escherichia coli
Biochemistry
33
6468-6474
1994
-
-
1
-
-
-
2
5
-
1
1
1
-
4
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
5
-
1
1
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209533
Ruiz van Haperen
Deoxycytidine kinase and deoxy ...
Homo sapiens
Eur. J. Cancer
29A
2132-2137
1993
-
1
-
-
-
-
-
-
-
-
-
-
-
4
-
-
1
-
-
9
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
9
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209663
Bouffard
Kinetic studies on 2',2'-diflu ...
Homo sapiens
Biochem. Pharmacol.
45
1857-1861
1993
-
1
-
-
-
-
2
2
-
-
-
1
-
4
-
-
1
-
-
3
1
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
2
-
-
-
1
-
-
-
1
-
3
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209532
Mancini
The role of deoxycytidine-meta ...
Homo sapiens
Cancer Chemother. Pharmacol.
30
139-144
1992
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209662
Barchi
-
Inhibition of cytidine deamina ...
Homo sapiens, Mus musculus, Mus musculus BALB/c
Nucleosides Nucleotides
11
1781-1793
1992
-
1
-
-
-
-
4
1
-
-
-
3
-
60
-
-
-
-
-
6
-
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
1
-
-
-
3
-
-
-
-
-
6
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209660
Kwon
-
Purification and properties of ...
Geobacillus stearothermophilus, Bacillus subtilis, Saccharomyces cerevisiae, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli JF611
Mol. Cells
1
281-286
1991
-
-
3
-
-
-
16
7
1
-
9
6
-
6
-
-
1
-
-
-
9
-
19
3
-
2
-
1
-
2
-
1
-
-
-
-
-
-
3
-
-
-
-
-
16
-
7
1
-
9
6
-
-
-
1
-
-
9
-
19
3
2
-
1
-
2
-
1
-
-
-
-
-
-
-
209661
Cacciamani
Purification of human cytidine ...
Canis lupus familiaris, Gallus gallus, Escherichia coli, Homo sapiens, Mus musculus, no activity in Lactobacillus sp., no activity in Moraxella sp., no activity in Pseudomonas sp., Mus musculus BALB/c
Arch. Biochem. Biophys.
290
285-292
1991
-
1
-
-
-
-
45
-
-
-
2
6
-
71
-
-
2
-
-
11
1
1
41
2
1
-
-
-
-
1
1
1
-
-
-
-
-
1
-
-
-
-
-
-
45
-
-
-
-
2
6
-
-
-
2
-
11
1
1
41
2
-
-
-
-
1
1
1
-
-
-
-
-
-
-
209657
Fanucchi
Kinetics and substrate specifi ...
Canis lupus familiaris, Homo sapiens
Biochem. Pharmacol.
35
1199-1201
1986
-
-
-
-
-
-
1
9
-
-
-
2
-
8
-
-
-
-
-
2
-
-
10
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
9
-
-
-
2
-
-
-
-
-
2
-
-
10
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209658
Vita
-
Further properties of cytidine ...
Escherichia coli, Escherichia coli B / ATCC 11303
Ital. J. Biochem.
35
145A-147A
1986
-
-
-
-
-
-
6
2
-
-
2
2
-
177
-
-
1
-
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6
-
2
-
-
2
2
-
-
-
1
-
-
-
-
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209659
Nygaard
On the role of cytidine deamin ...
Saccharomyces cerevisiae, Escherichia coli, Ovis aries, Homo sapiens, Mus musculus, no activity in Lactobacillus sp., no activity in Moraxella sp., no activity in Pseudomonas sp., Salmonella enterica subsp. enterica serovar Typhimurium, Zea mays, Mus musculus BALB/c
Adv. Exp. Med. Biol.
195B
415-420
1986
3
1
-
-
-
-
-
-
-
-
-
8
-
69
-
-
2
-
-
11
-
-
25
-
-
-
-
-
-
-
-
-
-
-
-
-
3
1
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
2
-
11
-
-
25
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209655
Vita
Cytidine deaminase from Escher ...
Escherichia coli, Escherichia coli B / ATCC 11303
Biochemistry
24
6020-6024
1985
-
-
-
-
-
-
9
3
-
-
3
2
-
183
-
-
1
-
-
-
-
4
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
3
-
-
3
2
-
-
-
1
-
-
-
4
6
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209656
Holy
-
Preparation of analogues of cy ...
Saccharomyces cerevisiae, Escherichia coli, Macaca mulatta, Mus musculus, Mus musculus BALB/c, Escherichia coli A19
Collect. Czech. Chem. Commun.
50
393-417
1985
-
-
-
-
-
1
5
-
-
-
-
6
-
65
-
-
1
-
-
3
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
5
-
-
-
-
-
6
-
-
-
1
-
3
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209652
Kidder
Characteristics of cytidine am ...
Crithidia fasciculata, Trypanosoma cruzi
J. Protozool.
31
298-300
1984
6
-
-
-
-
2
2
4
-
-
2
2
-
15
-
-
-
-
-
-
-
4
4
-
-
-
-
-
-
2
-
-
-
-
-
-
6
-
-
-
-
-
2
-
2
-
4
-
-
2
2
-
-
-
-
-
-
-
4
4
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
209653
Ashley
Purification and properties of ...
Saccharomyces cerevisiae, Escherichia coli, Ovis aries, Homo sapiens, Mus musculus, Zea mays, Escherichia coli B / ATCC 11303, Mus musculus BALB/c
J. Biol. Chem.
259
13615-13620
1984
-
-
-
-
-
-
9
3
-
-
5
8
-
245
-
-
5
-
-
5
1
2
26
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
3
-
-
5
8
-
-
-
5
-
5
1
2
26
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209654
Ashley
Inhibition of Escherichia coli ...
Escherichia coli, Homo sapiens
J. Biol. Chem.
259
13621-13627
1984
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209528
Chan
Differences in deoxycytidine m ...
Mus musculus
Biochem. J.
210
367-371
1983
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209650
Ashley
A phosphorus-containing pyrimi ...
Escherichia coli, Escherichia coli B / ATCC 11303
Biochem. Biophys. Res. Commun.
108
1467-1474
1982
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177
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209651
Kara
-
Sensitivity of some arabinosyl ...
Mus musculus, Mus musculus BALB/c
Collect. Czech. Chem. Commun.
47
2824-2830
1982
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2
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59
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13
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209492
Ipata
Cytosine and cytidine deaminas ...
Saccharomyces cerevisiae, Escherichia coli, Mus musculus, Mus musculus BALB/c
Methods Enzymol.
51
394-401
1978
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11
3
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4
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64
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8
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209527
Cullen
Bromodeoxyuridine induction of ...
Cricetinae, Mus musculus
Biochim. Biophys. Acta
517
158-168
1978
1
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209648
Wentworth
Cytidine deaminases (from Esch ...
Canis lupus familiaris, Cavia porcellus, Columba sp., Oryctolagus cuniculus, Escherichia coli, Felis catus domesticus, Homo sapiens, Macaca mulatta, Mus musculus, Rana sp., Rattus norvegicus, Sus scrofa, Escherichia coli B / ATCC 11303, Mus musculus BALB/c
Methods Enzymol.
51
401-407
1978
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4
7
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1
14
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247
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2
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15
1
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41
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14
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15
1
1
41
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3
1
1
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209649
Rothman
Cytidine deaminase from leukem ...
Homo sapiens, Mus musculus, Mus musculus BALB/c
Methods Enzymol.
51
408-412
1978
3
1
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7
3
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1
1
3
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65
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10
1
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21
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10
1
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21
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209645
Wentworth
On the interaction of 3,4,5,6- ...
Escherichia coli, Homo sapiens
Biochemistry
14
5099-5105
1975
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209646
Evans
The action of bacterial cytidi ...
Escherichia coli
Biochemistry
14
621-624
1975
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209526
Le Floc`h
-
La desoxycytidine aminohydrola ...
Zea mays
Phytochemistry
13
2503-2509
1974
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6
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209529
Kang
-
Metabolism of pyrimidine deoxy ...
Mus musculus
Korean J. Zool.
17
107-116
1974
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209643
Abell
Cytidine deaminase in human ly ...
Homo sapiens
Nature New Biol.
244
217-219
1973
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1
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209644
Hosono
The purification and propertie ...
Bacillus cereus, Saccharomyces cerevisiae, Escherichia coli, Ovis aries, Mus musculus, Mus musculus BALB/c, Escherichia coli Y-70-272
J. Biochem.
74
797-803
1973
5
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26
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26
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23
1
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209530
Taketo
Internal localization of nucle ...
Escherichia coli
J. Biochem.
72
1557-1563
1972
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209641
Cohen
Cytidine deaminase from Escher ...
Saccharomyces cerevisiae, Escherichia coli, Ovis aries, Homo sapiens, Mus musculus, Escherichia coli B / ATCC 11303, Mus musculus BALB/c
J. Biol. Chem.
246
7561-7565
1971
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7
4
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1
7
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241
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9
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7
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1
9
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209639
Wang
Enzymatic deamination of cytos ...
Bos taurus, Saccharomyces cerevisiae, Oryctolagus cuniculus, Escherichia coli, Mus musculus, Escherichia coli 15 (ATCC 9723), Mus musculus BALB/c
J. Biol. Chem.
184
17-28
1950
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1
2
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7
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64
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9
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