Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.4 extracted from

  • Lougiakis, N.; Marakos, P.; Pouli, N.; Fragopoulou, E.; Tenta, R.
    Synthesis of new nebularine analogues and their inhibitory activity against adenosine deaminase (2015), Chem. Pharm. Bull., 63, 134-142.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,2,2-trifluoro-N-[7-chloro-5-methyl-3-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-yl]-acetamide 20% inhibition at 0.4 mM Bos taurus
2,2,2-trifluoro-N-[7-chloro-5-methyl-3-(beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-yl]acetamide 23% inhibition at 0.4 mM Bos taurus
5-(beta-D-ribofuranosyl)-1H,5H-imidazo[4,5-b]pyrazolo[3,4-e]pyridine 25% inhibition at 0.4 mM Bos taurus
5-methyl-3-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-amine 19% inhibition at 0.4 mM Bos taurus
5-methyl-3-(beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-amine 6% inhibition at 0.4 mM Bos taurus
5-methyl-6-nitro-3-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridine 31% inhibition at 0.4 mM Bos taurus
5-methyl-6-nitro-3-(beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridine 25% inhibition at 0.4 mM Bos taurus
7-(beta-D-ribofuranosyl)-1H,7H-imidazo[4,5-b]pyrazolo[3,4-e]pyridine 7% inhibition at 0.4 mM Bos taurus
7-chloro-5-methyl-3-(beta-D-ribofuranosyl)-3H-imidazo[4,5-b]pyridin-6-amine 15% inhibition at 0.4 mM Bos taurus
nebularine i.e. 9-beta-D-ribofuranosylpurine, competitive inhibitor Bos taurus
pentostatin
-
Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
adenosine + H2O Bos taurus
-
inosine + NH3
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus P56658
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O
-
Bos taurus inosine + NH3
-
?

Synonyms

Synonyms Comment Organism
ADA
-
Bos taurus