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Literature summary for 3.5.4.4 extracted from

  • Kamat, S.S.; Bagaria, A.; Kumaran, D.; Holmes-Hampton, G.P.; Fan, H.; Sali, A.; Sauder, J.M.; Burley, S.K.; Lindahl, P.A.; Swaminathan, S.; Raushel, F.M.
    Catalytic mechanism and three-dimensional structure of adenine deaminase (2011), Biochemistry, 50, 1917-1927.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.4

Protein Variants

Protein Variants Comment Organism
D172 mutant is 40% less active than the wild-type. Mutant is more thightly bound to erythro-9-(2-hydroxy-3-nonly)adenine (Ki: 0.0009 mM) than wild-type Plasmodium vivax

Inhibitors

Inhibitors Comment Organism Structure
(2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol
-
 Plasmodium vivax

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.071
-
 adenosine wild-type, pH 7.5, 37°C Plasmodium vivax

Organism

Organism UniProt Comment Textmining
Plasmodium vivax
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
adenosine + H2O
-
 Plasmodium vivax inosine + NH3
-
 ?

Synonyms

Synonyms Comment Organism
PvADA
-
 Plasmodium vivax

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Plasmodium vivax

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Plasmodium vivax

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0009
-
 (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol mutant D172A, pH 7.5, 30°C Plasmodium vivax
0.0019
-
 (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-2-ol wild-type, pH 7.5, 30°C Plasmodium vivax