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Literature summary for 3.5.4.4 extracted from
- Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity (2005), Biochem. J., 391, 51-57.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| erythro-9-(2-hydroxy-3-nonyl)adenine | i.e. EHNA | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine + H2O | Homo sapiens | isozyme ADA2 is important in lymphocyte activation, and may be active in sites of inflammation and during hypoxia and in areas of tumor growth with elevated adenosine levels and acidic pH, overview | inosine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NZK5 | isozyme ADA2 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| isozyme ADA2, 138.3fold by immunoglobulin and heparin affinity chromatography in two alternated sequences, and gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lymphocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 166 | - |
purified isozyme ADA2 | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| adenosine + H2O | - |
Homo sapiens | inosine + NH3 | - |
? | |
| adenosine + H2O | isozyme ADA2 is important in lymphocyte activation, and may be active in sites of inflammation and during hypoxia and in areas of tumor growth with elevated adenosine levels and acidic pH, overview | Homo sapiens | inosine + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ADA | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.6 | 8.2 | isozyme ADA2 | Homo sapiens |
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Release 2023.1 (January 2023)
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