Literature summary for 3.5.4.4 extracted from

Mardanyan, S.S.; Sharoyan, S.G.; Antonyan, A.A.; Lupidi, G.; Cristalli, G.
Interaction of adenosine deaminase with inhibitors. Chemical modification by diethyl pyrocarbonate (2002), Biochemistry (Moscow), 67, 770-777.

Search for more literature for 3.5.4.4

Inhibitors

Inhibitors	Comment	Organism	Structure
1-deazaadenosine	-	Bos taurus
diethyl dicarbonate	-	Bos taurus
erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine	-	Bos taurus
erythro-9-(2-hydroxy-3-nonyl)-adenine	-	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spleen	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
adenosine + H2O	-	Bos taurus	inosine + NH3	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	the adenine moiety of inhibitors does not bind to the histidine residues of the active site His238	Bos taurus
0.00007	-	erythro-9-(2-hydroxy-3-nonyl)-adenine	pH 7.1, 23°C, after preincubation with diethyl dicarbonate	Bos taurus
0.00008	-	erythro-9-(2-hydroxy-3-nonyl)-adenine	pH 7.1, 23°C	Bos taurus
0.00009	-	diethyl dicarbonate	pH 7.1, 23°C, in presence of 0.022 mM erythro-9-(2-hydroxy-3-nonyl)-adenine	Bos taurus
0.00011	-	erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine	pH 7.1, 23°C, after preincubation with diethyl dicarbonate	Bos taurus
0.00013	-	diethyl dicarbonate	pH 7.1, 23°C, in presence of 0.03 mM erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine	Bos taurus
0.00014	-	erythro-9-(2-hydroxy-3-nonyl)-3-deazaadenine	pH 7.1, 23°C	Bos taurus
0.007	-	1-deazaadenosine	pH 7.1, 23°C	Bos taurus
0.0074	-	1-deazaadenosine	pH 7.1, 23°C, after preincubation with diethyl dicarbonate	Bos taurus
0.01	-	diethyl dicarbonate	pH 7.1, 23°C, in presence of 0.008 mM 1-deazaadenosine	Bos taurus

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Release 2023.1 (January 2023)