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Literature summary for 3.5.4.38 extracted from

  • Cheng, H.L.; Vuong, B.Q.; Basu, U.; Franklin, A.; Schwer, B.; Astarita, J.; Phan, R.T.; Datta, A.; Manis, J.; Alt, F.W.; Chaudhuri, J.
    Integrity of the AID serine-38 phosphorylation site is critical for class switch recombination and somatic hypermutation in mice (2009), Proc. Natl. Acad. Sci. USA, 106, 2717-2122.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.38

Protein Variants

Protein Variants Comment Organism
S38A mutant form of activation-induced cytidine deaminase that retains similar catalytic activity on ssDNA as wild-type enzyme. The AIDS38A mutant protein is significantly compromised in its ability to mediate somatic hypermutation SHM. B cells homozygous for the AIDS38A mutation show substantially impaired class switch recombination and Ig somatic hypermutation, correlating with inability of AIDS38A to interact with endogenous replication protein A. Mice haploinsufficient for AIDS38A have more severely impaired class switch recombination when compared with mice haploinsufficient for AIDWT, with class switch recombination levels reduced to nearly background levels. These results unequivocally demonstrate that integrity of the AID S38 phosphorylation site is required for normal class switch recombination and Ig somatic hypermutation in mice and support a role for AID phosphorylation at S38 and replication protein A interaction in regulating class switch recombination and Ig somatic hypermutation Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Mus musculus the enzyme initiates Ig heavy chain (IgH) class switch recombination and Ig somatic hypermutation (SHM) by deaminating cytidines within, respectively, IgH switch regions and Ig variable region (V) exons uracil in single-stranded DNA + NH3
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WVE0
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein activation-induced cytidine deaminase that is phosphorylated on serine residue 38 interacts with replication protein A, a ssDNA binding protein, to promote deamination of transcribed double-stranded DNA in vitro. The Ser38 phosphorylation site is required for normal class switch recombination and Ig somatic hypermutation in mice Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
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 Mus musculus uracil in single-stranded DNA + NH3
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 ?
cytosine in single-stranded DNA + H2O the enzyme initiates Ig heavy chain (IgH) class switch recombination and Ig somatic hypermutation (SHM) by deaminating cytidines within, respectively, IgH switch regions and Ig variable region (V) exons Mus musculus uracil in single-stranded DNA + NH3
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 ?

Synonyms

Synonyms Comment Organism
activation-induced deaminase
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 Mus musculus
AID
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 Mus musculus