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Literature summary for 3.5.4.38 extracted from
- Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase (2003), Proc. Natl. Acad. Sci. USA, 100, 4102-4107.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine in single-stranded DNA + H2O | Homo sapiens | - |
uracil in single-stranded DNA + NH3 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9GZX7 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cytosine in single-stranded DNA + H2O | - |
Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
| cytosine in single-stranded DNA + H2O | no detectable activity on double-stranded DNA. The enzyme catalyzes deoxycytidine to deoxyuridine deamination activity on double-stranded DNA substrates containing a small transcription-like single-stranded DNA bubble. Enzyme activity depends on sequence context | Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| activation-induced deaminase | - |
Homo sapiens |
| AID | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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