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Literature summary for 3.5.4.38 extracted from

  • Gazumyan, A.; Timachova, K.; Yuen, G.; Siden, E.; Di Virgilio, M.; Woo, E.M.; Chait, B.T.; San-Martin, B.R.; Nussenzweig, M.C.; McBride, K.M.
    Amino-terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation (2011), Mol. Cell. Biol., 31, 442-449.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.38

Protein Variants

Protein Variants Comment Organism
S3A purified recombinant mutant enzyme S3A and wild-type have similar deamination activities on an ssDNA substrate in vitro. AID-/- B cells expressing AIDS3A show a consistently higher percentage of class-switched IgG1-expressing B cells than control enzyme. Mutating S3 to A does not alter catalysis but does result in increased AID activity in class switch recombination Mus musculus
S3D AID-/- B cells expressing AID-S3D show a consistently higher percentage of class-switched IgG1-expressing B cells than control enzyme. Mutating S3 to A does not alter catalysis but does result in increased AID activity in class switch recombination Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Mus musculus the enzyme initiates class switch recombination and somatic hypermutation of immunoglobulin genes in B lymphocytes. Activation-induced cytidine deaminase also produces off-target DNA damage, including mutations in oncogenes and double-stranded breaks that can serve as substrates for oncogenic chromosomal translocations uracil in single-stranded DNA + NH3
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9WVE0
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-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein phosphorylation at serine 38 and threonine 140 increases activity. Activation-induced cytidine deaminase activity and its oncogenic potential can be downregulated by phosphorylation of Ser3. This process is controlled by serine/threonine protein phosphatase 2A Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
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 Mus musculus uracil in single-stranded DNA + NH3
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 ?
cytosine in single-stranded DNA + H2O the enzyme initiates class switch recombination and somatic hypermutation of immunoglobulin genes in B lymphocytes. Activation-induced cytidine deaminase also produces off-target DNA damage, including mutations in oncogenes and double-stranded breaks that can serve as substrates for oncogenic chromosomal translocations Mus musculus uracil in single-stranded DNA + NH3
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 ?

Synonyms

Synonyms Comment Organism
activation-induced cytidine deaminase
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 Mus musculus
AID
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 Mus musculus

General Information

General Information Comment Organism
physiological function the enzyme initiates class switch recombination and somatic hypermutation of immunoglobulin genes in B lymphocytes. Activation-induced cytidine deaminase also produces off-target DNA damage, including mutations in oncogenes and double-stranded breaks that can serve as substrates for oncogenic chromosomal translocations Mus musculus