Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | Homo sapiens | the enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences | uracil in single-stranded DNA + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9GZX7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine in single-stranded DNA + H2O | the enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences | Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? | |
cytosine in single-stranded DNA + H2O | exclusively catalyses deamination of cytidine in single-stranded DNA. It shows minimal activity on stem-loop structures and preferentially deaminates five-nucleotide bubbles. The optimal target consists of a single-stranded NWRCN motif (W = A or T, R = A or G). WRC preference involves the recognition of a purine in the R position and that the carbonyl or amino side chains of guanosine negatively influence specificity at the W position | Homo sapiens | uracil in single-stranded DNA + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
activation-induced deaminase | - |
Homo sapiens |
AID | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme initiates antibody diversification processes by deaminating immunoglobulin sequences | Homo sapiens |