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Literature summary for 3.5.4.38 extracted from

  • McBride, K.M.; Gazumyan, A.; Woo, E.M.; Schwickert, T.A.; Chait, B.T.; Nussenzweig, M.C.
    Regulation of class switch recombination and somatic mutation by AID phosphorylation (2008), J. Exp. Med., 205, 2585-2594.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.38

Protein Variants

Protein Variants Comment Organism
S38A mutation does not impact catalytic activity, but interfers with class switching and somatic hypermutation in vivo Mus musculus
T140A mutation does not impact catalytic activity, but interfers with class switching and somatic hypermutation in vivo Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Mus musculus activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-stranded DNA breaks in the switch region DNA. The enzyme can also produce off-target DNA damage, including mutations in oncogenes uracil in single-stranded DNA + NH3
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Organism

Organism UniProt Comment Textmining
Mus musculus Q9WVE0
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein in addition to Ser38, the enzyme is also phosphorylated at position Thr140. Mutation of either Ser38 or Thr140 to Ala does not impact catalytic activity, but interfers with class switching and somatic hypermutation in vivo. Ser38 is equally important for both processes, Thr140 phosphorylation preferentially affects somatic mutation Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
B-lymphocyte
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 Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
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 Mus musculus uracil in single-stranded DNA + NH3
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 ?
cytosine in single-stranded DNA + H2O activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-stranded DNA breaks in the switch region DNA. The enzyme can also produce off-target DNA damage, including mutations in oncogenes Mus musculus uracil in single-stranded DNA + NH3
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 ?

Synonyms

Synonyms Comment Organism
activation-induced cytidine deaminase
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 Mus musculus
AID
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 Mus musculus

General Information

General Information Comment Organism
physiological function activation-induced cytidine deaminase (AID) is a mutator enzyme that initiates somatic mutation and class switch recombination in B lymphocytes by introducing uracil:guanine mismatches into DNA. Repair pathways process these mismatches to produce point mutations in the Ig variable region or double-stranded DNA breaks in the switch region DNA. The enzyme can also produce off-target DNA damage, including mutations in oncogenes Mus musculus