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Literature summary for 3.5.4.38 extracted from

  • Wang, J.H.
    The role of activation-induced deaminase in antibody diversification and genomic instability (2013), Immunol. Res., 55, 287-297.
    View publication on PubMed
Search for more literature for 3.5.4.38

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine in single-stranded DNA + H2O Homo sapiens activation-induced deaminase is the initiator for somatic hypermutation (SHM) and class switch recombination (CSR). The enzyme targets the highly repetitive switch regions of the immunoglobulin heavy chain locus to induce DNA double-strand breaks (DSBs), which can be rejoined, leading to switch of constant regions of antibody. When targeting to variable region exons of IgH and IgL loci, the enzyme predominantly induces point mutations, termed SHM, resulting in increased affinity of antibody for antigen. While somatic hypermutation and class switch recombination (CSR) enhance antibody diversity, activation-induced deaminase initiated double-strand breaks and mutations may predispose B cells to carcinogenesis uracil in single-stranded DNA + NH3
-
 ?
cytosine in single-stranded DNA + H2O Mus musculus activation-induced deaminase is the initiator for somatic hypermutation (SHM) and class switch recombination (CSR). The enzyme targets the highly repetitive switch regions of the immunoglobulin heavy chain locus to induce DNA double-strand breaks (DSBs), which can be rejoined, leading to switch of constant regions of antibody. When targeting to variable region exons of IgH and IgL loci, the enzyme predominantly induces point mutations, termed SHM, resulting in increased affinity of antibody for antigen. While somatic hypermutation and class switch recombination (CSR) enhance antibody diversity, AID initiated double-strand breaks and mutations may predispose B cells to carcinogenesis uracil in single-stranded DNA + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9GZX7
-
-
Mus musculus Q9WVE0
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cytosine in single-stranded DNA + H2O
-
 Homo sapiens uracil in single-stranded DNA + NH3
-
 ?
cytosine in single-stranded DNA + H2O
-
 Mus musculus uracil in single-stranded DNA + NH3
-
 ?
cytosine in single-stranded DNA + H2O activation-induced deaminase is the initiator for somatic hypermutation (SHM) and class switch recombination (CSR). The enzyme targets the highly repetitive switch regions of the immunoglobulin heavy chain locus to induce DNA double-strand breaks (DSBs), which can be rejoined, leading to switch of constant regions of antibody. When targeting to variable region exons of IgH and IgL loci, the enzyme predominantly induces point mutations, termed SHM, resulting in increased affinity of antibody for antigen. While somatic hypermutation and class switch recombination (CSR) enhance antibody diversity, activation-induced deaminase initiated double-strand breaks and mutations may predispose B cells to carcinogenesis Homo sapiens uracil in single-stranded DNA + NH3
-
 ?
cytosine in single-stranded DNA + H2O activation-induced deaminase is the initiator for somatic hypermutation (SHM) and class switch recombination (CSR). The enzyme targets the highly repetitive switch regions of the immunoglobulin heavy chain locus to induce DNA double-strand breaks (DSBs), which can be rejoined, leading to switch of constant regions of antibody. When targeting to variable region exons of IgH and IgL loci, the enzyme predominantly induces point mutations, termed SHM, resulting in increased affinity of antibody for antigen. While somatic hypermutation and class switch recombination (CSR) enhance antibody diversity, AID initiated double-strand breaks and mutations may predispose B cells to carcinogenesis Mus musculus uracil in single-stranded DNA + NH3
-
 ?

Synonyms

Synonyms Comment Organism
activation-induced deaminase
-
 Homo sapiens
activation-induced deaminase
-
 Mus musculus
AID
-
 Homo sapiens
AID
-
 Mus musculus

General Information

General Information Comment Organism
metabolism activation-induced deaminase initiated double-strand breaks and mutations may predispose B cells to carcinogenesis Homo sapiens