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Literature summary for 3.5.4.32 extracted from

  • Zhang, X.; Zhao, Y.; Duan, X.; Zhang, H.; Cao, Z.; Mo, Y.
    Mechanisms for the deamination reaction of 8-oxoguanine catalyzed by 8-oxoguanine deaminase a combined QM/MM molecular dynamics study (2016), J. Theor. Comput. Chem., 15, 1650066 .
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Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q9I6Z0
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-
Pseudomonas aeruginosa DSM 22644 Q9I6Z0
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
8-oxoguanine + H2O
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 Pseudomonas aeruginosa urate + NH3
-
 ?
8-oxoguanine + H2O
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 Pseudomonas aeruginosa DSM 22644 urate + NH3
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 ?
additional information the rate-limiting step corresponds to the nucleophilic attack from the zinc-coordinating hydroxide group to free 8-oxoguanine. Residues Trp115, Trp123 and Leu119 connect to O8 of 8-oxoguanine with hydrogen bonds. Both Glu218 and a water molecule can be used as proton shuttles, and a water molecule plays a major role in proton transfer to the substrate Pseudomonas aeruginosa ?
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 ?
additional information the rate-limiting step corresponds to the nucleophilic attack from the zinc-coordinating hydroxide group to free 8-oxoguanine. Residues Trp115, Trp123 and Leu119 connect to O8 of 8-oxoguanine with hydrogen bonds. Both Glu218 and a water molecule can be used as proton shuttles, and a water molecule plays a major role in proton transfer to the substrate Pseudomonas aeruginosa DSM 22644 ?
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 ?

Synonyms

Synonyms Comment Organism
8-oxoGD
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 Pseudomonas aeruginosa
Pa0142
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 Pseudomonas aeruginosa