Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.4.25 extracted from

  • Yadav, S.; Karthikeyan, S.
    Structural and biochemical characterization of GTP cyclohydrolase II from Helicobacter pylori reveals its redox dependent catalytic activity (2015), J. Struct. Biol., 192, 100-115 .
    View publication on PubMed
Search for more literature for 3.5.4.25

Crystallization (Commentary)

Crystallization (Comment) Organism
the enzyme is crystallized in oxidized form, the expulsion of Zn(2+) upon oxidation of catalytic cysteines reveales its ability to act in response to the redox environment. The crystal structure of Helicobacter pylori, unlike other GCHII structures, reveales that cysteines at the active site exist in oxidized state forming two disulfide bonds Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + 3 H2O Helicobacter pylori
-
 formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate
-
 ?
GTP + 3 H2O Helicobacter pylori ATCC 700392
-
 formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori O08315
-
-
Helicobacter pylori ATCC 700392 O08315
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + 3 H2O
-
 Helicobacter pylori formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate
-
 ?
GTP + 3 H2O
-
 Helicobacter pylori ATCC 700392 formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
GCHII
-
 Helicobacter pylori

General Information

General Information Comment Organism
metabolism the enzyme is essential for pathogens. The enzyme can regulate its catalytic activity depending on the redox environment Helicobacter pylori