Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EDTA | the enzyme is rapidly and completely inactivated by EDTA | Escherichia coli |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Escherichia coli | |
Zn2+ | contains Zn2+ | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Escherichia coli | - |
formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate | GMP is a second reaction product of GTP cyclohydrolase II. The ratio of the main product, 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine and GMP is produced at an approximate ratio of 10:1 | ? | |
additional information | Escherichia coli | GTP cyclohydrolase II is a slow GTPase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0A7I7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone 5'-triphosphate + H2O | - |
Escherichia coli | ? | - |
? | |
GTP + H2O | - |
Escherichia coli | formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate | GMP is a second reaction product of GTP cyclohydrolase II. The ratio of the main product, 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine and GMP is produced at an approximate ratio of 10:1 | ? | |
additional information | GTP cyclohydrolase II is a slow GTPase | Escherichia coli | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCH-II | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
metabolism | GTP cyclohydrolase II catalyzes the first committed step in the biosynthesis of riboflavin | Escherichia coli |