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Literature summary for 3.5.4.25 extracted from

  • Bacher, A.; Richter, G.; Ritz, H.; Eberhardt, S.; Fischer, M.; Krieger, C.
    Biosynthesis of riboflavin: GTP-cyclohydrolase II, deaminase, and reductase (1997), Methods Enzymol., 280, 382-389.
    View publication on PubMed
Search for more literature for 3.5.4.25

Inhibitors

Inhibitors Comment Organism Structure
diphosphate competitive inhibitor Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.3
-
 GTP
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22000
-
 alpha2, 2 * 22000, SDS-PAgGE Escherichia coli
44000
-
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Escherichia coli
-
 formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Escherichia coli formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate
-
 ?

Subunits

Subunits Comment Organism
dimer alpha2, 2 * 22000, SDS-PAgGE Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.15
-
 GTP
-
 Escherichia coli