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Literature summary for 3.5.4.24 extracted from
- Studies on sepiapterin deaminase from the silkworm, Bombyx mori. Purification and some properties of the enzyme (1971), J. Biochem., 69, 781-788.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2,4-Dihydroxypteridine | 0.2 mM, 15% inhibition | Bombyx mori |  |
| 2-Amino-4-hydroxypteridine | most effective competitive inhibitor, 0.2 mM, 85% inhibition | Bombyx mori | |
| 2-amino-4-hydroxypteridine-6-carboxylic acid | 0.2 mM, 26% inhibition | Bombyx mori | |
| adenine | 0.2 mM, 27% inhibition | Bombyx mori | |
| aminopterin | 0.2 mM, 58% inhibition | Bombyx mori | |
| biopterin | most effective inhibitor, 0.2 mM, 84% inhibition | Bombyx mori | |
| guanine | 0.2 mM, 59% inhibition | Bombyx mori | |
| uric acid | 0.2 mM, 9% inhibition | Bombyx mori | |
| Xanthopterin | competitive inhibitor, 0.2 mM, 61% inhibition | Bombyx mori | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.59 | - |
sepiapterin | - |
Bombyx mori | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sepiapterin + H2O | Bombyx mori | - |
xanthopterin-B2 + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bombyx mori | - |
silkworm, normal type, mutant lemon | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Bombyx mori |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| fat body | - |
Bombyx mori | - |
| gonad | - |
Bombyx mori | - |
| integument | larval integument, mutant lemon | Bombyx mori | - |
| midgut | - |
Bombyx mori | - |
| silk gland | - |
Bombyx mori | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 2.15 | - |
- |
Bombyx mori |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 3°C 15% decrease in enzyme activity after 1 month | Bombyx mori |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| isosepiapterin + H2O | less effectively deaminated | Bombyx mori | ? | - |
? | |
| sepiapterin + H2O | - |
Bombyx mori | xanthopterin-B2 + NH3 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
in potassium phosphate or Tris-HCl buffer | Bombyx mori |
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